Consensus guidelines for the management of adult high-grade gliomas for lowand middle-income countries

Abstract

High-grade glioma (HGG), a formidable and often
incurable disease, presents an even greater challenge in
low- and middle-income countries (LMICs) where
resources and medical expertise are scarce. This scarcity
not only exacerbates the suffering of patients but also
contributes to poorer clinical outcomes. Particularly in
LMICs, the underrepresentation of the population in
clinical trials and the additional hurdles posed by financial
constraints underscore an urgent need for contextspecific
management strategies. In response, we have
rigorously evaluated recent guidelines from leading
medical societies, adapting them to suit the specific
needs and limitations of the local context in Pakistan. This
effort, undertaken in collaboration with local physicians,
aims to provide a comprehensive, standardised approach
to diagnose, treat, and follow-up with HGG patients. By
focussing on the best available clinical evidence and
judicious use of limited resources, we strive to improve
patient care and outcomes in these challenging settings.
Keywords: Patient care, societies, medical, physicians,
glioma, brain tumour,