Prognostic significance of FOXP3+ tumour-infiltrating Tregs in Egyptian breast cancer patients Authors Mohamed Mkayed Abdel Kader Department of Pathology, Kafrelsheikh University, Egypt. Eman Mohamed. Saied Department of Pathology, Kafrelsheikh University, Egypt. Safinaz Hussein. ElShourbagy Department of Pathology, Tanta University, Egypt. Noha Mohamed El-Anwar Department of Pathology, Tanta University, Egypt. DOI: https://doi.org/10.47391/JPMA.EGY-S4-30 Keywords: T-Lymphocytes, Prognosis, Immunohistochemistry, Breast neoplasms, X chromosome Abstract Objective: To evaluate the prognostic importance of tumour-infiltrating forkhead box P3 protein + regulatory T cells in breast cancer patients.Methods: The case-control study was conducted from January 2020 to March 2021 at the Kafrelsheikh University Hospital, Egypt, and comprised individuals with newly-diagnosed breast cancer who underwent conventional surgery,and controls who had a fibrocystic change of the breast. The density of tumour-infiltrating forkhead box P3 protein + regulatory T cells was assessed by immunohistochemistry. Overall survival and disease free-survival were assessed.Data was analysed using SPSS 25.Results: Of the 100 patients having mean age 44.9±9.1 years, 76(76%) had moderate/strong forkhead box P3 protein expression in tumour-infiltrating regulatory T cells, and 24(24%) with no/low expression. On follow-up, Patients with moderate/strong expression had a significantly greater rate of recurrence (p<0.05). Disease-free survival was substantially shorter in patients with moderate/strong expression compared to those with little or low expression (p=0.035). Compared to individuals with no/low expression, patients with moderate/strong expression had a greater rate of mortality, but the difference was not statistically significant (p>0.05).Conclusions: High density of forkhead box P3 protein + regulatory T cells in Egyptian women with breast cancer may serve as a prognostic indicator.Keywords: T-Lymphocytes, Prognosis, Immunohistochemistry, Breast neoplasms, X chromosome. Downloads Full Text Article Published 2023-05-25 How to Cite Mohamed Mkayed Abdel Kader, Eman Mohamed. Saied, Safinaz Hussein. ElShourbagy, & Noha Mohamed El-Anwar. (2023). Prognostic significance of FOXP3+ tumour-infiltrating Tregs in Egyptian breast cancer patients. Journal of the Pakistan Medical Association, 73(4), S146-S150. https://doi.org/10.47391/JPMA.EGY-S4-30 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 4 (2023): Climate Change and the need for One World One Health Section RESEARCH ARTICLE License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.