Diffuse large B-cell lymphoma as an extra-hepatic manifestation of hepatitis C and co-infection of helicobacter pylori: A case report Authors Naresh Kumar Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan Amanullah Abbasi Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan Sana Muhammad Hussain Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan Aysal Mahmood Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan Kanhiyalal Talreja Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.9458 Keywords: Hepatitis C, Non-Hodgkin Lymphoma, Helicobacter pylori Abstract Along with infecting hepatocytes, the Hepatitis C virus (HCV) is also a lymphotropic virus. Chronic HCV infection can mutate the Bcl2, a proto-oncogene that inhibits apoptosis. This causes continuous stimulation of B lymphocytes, which results in clonal growth of these immunoglobulin-producing cells. In Western countries, there is a well-documented link between HCV and lymphoproliferative illness. HCV and Non-Hodgkin lymphoma (NHL) have been found to be significantly correlated in Europe, Japan, and the southern United States. There, however, has been no association found in central and northern Europe, the northwestern United States, and some Asian countries. A literature deficit exists in South Asia about the incidence of HCV infection in lymphoma patients. Here, the first documented instance of Diffuse Large B-cell NHL (germinal center type) is reported in a 35-year-old patient. ---Continue Downloads Full Text Article Published 2024-04-22 How to Cite Kumar, N., Abbasi, A., Hussain, S. M., Mahmood, A., & Talreja, K. (2024). Diffuse large B-cell lymphoma as an extra-hepatic manifestation of hepatitis C and co-infection of helicobacter pylori: A case report. Journal of the Pakistan Medical Association, 74(5), 980–983. https://doi.org/10.47391/JPMA.9458 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 5 (2024): MAY Section CASE REPORT License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.