Role of stem cells in the treatment of osteoarthritis- a review of literature

Authors

  • Mohammad Mustafa Department of Orthopaedics, Liaquat National Hospital, Karachi, Pakistan
  • Arslan Ahmed Abro Department of Orthopaedics, Liaquat National Hospital, Karachi, Pakistan
  • Noman Khan Department of Orthopaedics, Liaquat National Hospital, Karachi, Pakistan
  • Muhammmad Kazim Rahim Najjad Department of Orthopaedics, Liaquat National Hospital, Karachi, Pakistan
  • Syed Shahid Noor Department of Orthopaedics, Liaquat National Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.AKUS-15

Abstract

The purpose of this review was to identify and assess the effectiveness of stem cells in the form of injectables in the treatment of joint osteoarthritis as published  in the literature. Studies were searched from multiple databases like Pubmed, Embase and Cochrane Library until June 2022 using multiple keywords. Randomized controlled trials of patients with osteoarthritis (OA) were included which compared the pain and functional outcomes for those getting Mesenchymal Stem Cells (MSCs) injectables as compared to those who received no MSCs injection. Twelve randomized controlled trials, assessing a total of 486 participants were identified and studied. Overall, stem cells injection has no significant effect on pain along with physical function.

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Published

2023-01-25

How to Cite

Mohammad Mustafa, Arslan Ahmed Abro, Noman Khan, Muhammmad Kazim Rahim Najjad, & Syed Shahid Noor. (2023). Role of stem cells in the treatment of osteoarthritis- a review of literature. Journal of the Pakistan Medical Association, 73(2), S93-S97. https://doi.org/10.47391/JPMA.AKUS-15

Issue

Vol. 73 No. 2 (2023): Stem Cells: A New Frontier in Surgery

Section

REVIEW ARTICLE