Association of podoplanin expression to histopathological grades of oral epithelial dysplasia and oral squamous cell carcinoma Authors Hina Shabir Rehman College of Dentistry, Peshawar, Pakistan Sofia Haider Durrani Sardar Begum Dental College, Peshawar, Pakistan Sahibzade Fatima Tariq Rehman College of Dentistry, Peshawar, Pakistan Sana Salam Khatak Sardar Begum Dental College, Peshawar, Pakistan Abbas Saleem Khan Peshawar Dental College, Peshawar, Pakistan Kanwal Nazir Arbab Rehman College of Dentistry, Peshawar, Pakistan DOI: https://doi.org/10.47391/JPMA.8277 Keywords: Oral epithelial dysplasia, Oral squamous cell carcinoma, Podoplanin Abstract Objective: To determine the expression of podoplanin, and to correlate it with histopathological grades in oral epithelial dysplasia and oral squamous cell carcinoma cases. Methods: The retrospective, analytical, cross-sectional study was conducted at the City Laboratory, Peshawar, Pakistan, and comprised specimen block data of histologically diagnosed cases of oral benign lesions, dysplastic lesions and oral squamous cell carcinoma from January 2017 to August 2021. Two sections (4um) were cut from each specimen block for Haematoxylin and Eosin staining and immunohistochemistry. The slides were re-evaluated by two pathologists for confirmation of the diagnosis, and podoplanin marker was applied to cases selected using immunohistochemistry. Data was analysed using SPSS 22. Results: Of the 80 cases identified, 68(85%) were analysed. There were 20(29.4%) benign cases; 11(55%) females and 9(45%) males with mean age 39.90±16.23 years, 20(29.4%) oral dysplastic cases; 14(70%) males and 6(30%) females with mean age 57.75±12.02 years, and 28(41.2%) oral squamous cell carcinoma cases; 17(61%) males and 11(39%) females with mean age 50.55±14.80 years. Podoplanin expression in oral epithelial dysplasia cases was significant (p=0.028), while it was not significant in the other 2 groups (p>0.05). Conclusion: Podoplanin when used along with histopathological evaluation could help in the diagnosis and grading of oral epithelial dysplasia lesions. Key Words: Oral epithelial dysplasia, Oral squamous cell carcinoma, Podoplanin. Author Biography Sana Salam Khatak, Sardar Begum Dental College, Peshawar, Pakistan Oral Pathology, Senior Lecturer Downloads Full Text Article Published 2024-04-22 How to Cite Shabir, H., Haider Durrani, S., Tariq, S. F., Salam Khatak, S., Saleem Khan, A., & Nazir Arbab, K. (2024). Association of podoplanin expression to histopathological grades of oral epithelial dysplasia and oral squamous cell carcinoma. Journal of the Pakistan Medical Association, 74(5), 852–856. https://doi.org/10.47391/JPMA.8277 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 5 (2024): MAY Section RESEARCH ARTICLE License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.