A case of Juvenile Systemic Lupus Erythematosus in a pre-pubertal child with atopic eczema

Authors

  • Ghazal Afzal Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan
  • Shakila Junaid Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan
  • Fatima Zahoor Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.8084

Keywords:

IgE therapy, Atopic dermatitis, Juvenile autoimmune connective tissue disease, Serum IgE, Neuropsychiatric

Abstract

Juvenile Systemic Lupus Erythematosus (JSLE) is a subset of SLE, with onset before eighteen years of age and associated with increased mortality and morbidity. JSLE is a complex autoimmune disease with respect to its underlying genetics. It is characterised by the disruption of immune tolerance, resulting in cascade of immune responses including the Th2 response with production of interleukins (ILs) 4,5,10, as seen with allergic disorders. Along with this, polyclonal activation of B lymphocytes results in the production of autoantibodies, particularly of the IgG, IgM and antinuclear IgE autoantibodies. JSLE is frequently recognized in girls. The purpose of this case report is to share an uncommon presentation of JSLE in a 8-year-old boy who was diagnosed as a case of atopic eczema at the age of 8 months and later on, at the age of 4 years,

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Author Biographies

Ghazal Afzal, Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan

Postgraduate trainee

Shakila Junaid, Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan

consultant dermatologist 

Fatima Zahoor, Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan

postgraduate trainee

Published

2024-07-25

How to Cite

Afzal, G., Junaid, S., & Zahoor, F. (2024). A case of Juvenile Systemic Lupus Erythematosus in a pre-pubertal child with atopic eczema. Journal of the Pakistan Medical Association, 74(8), 1521–1523. https://doi.org/10.47391/JPMA.8084

Issue

Section

CASE REPORT