A case of Juvenile Systemic Lupus Erythematosus in a pre-pubertal child with atopic eczema Authors Ghazal Afzal Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan Shakila Junaid Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan Fatima Zahoor Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.8084 Keywords: IgE therapy, Atopic dermatitis, Juvenile autoimmune connective tissue disease, Serum IgE, Neuropsychiatric Abstract Juvenile Systemic Lupus Erythematosus (JSLE) is a subset of SLE, with onset before eighteen years of age and associated with increased mortality and morbidity. JSLE is a complex autoimmune disease with respect to its underlying genetics. It is characterised by the disruption of immune tolerance, resulting in cascade of immune responses including the Th2 response with production of interleukins (ILs) 4,5,10, as seen with allergic disorders. Along with this, polyclonal activation of B lymphocytes results in the production of autoantibodies, particularly of the IgG, IgM and antinuclear IgE autoantibodies. JSLE is frequently recognized in girls. The purpose of this case report is to share an uncommon presentation of JSLE in a 8-year-old boy who was diagnosed as a case of atopic eczema at the age of 8 months and later on, at the age of 4 years, ---Continue Author Biographies Ghazal Afzal, Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan Postgraduate trainee Shakila Junaid, Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan consultant dermatologist Fatima Zahoor, Department of Dermatology, PNS Shifa Hospital, Karachi, Pakistan postgraduate trainee Downloads Full Text Article Published 2024-07-25 How to Cite Afzal, G., Junaid, S., & Zahoor, F. (2024). A case of Juvenile Systemic Lupus Erythematosus in a pre-pubertal child with atopic eczema. Journal of the Pakistan Medical Association, 74(8), 1521–1523. https://doi.org/10.47391/JPMA.8084 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 8 (2024): AUGUST Section CASE REPORT License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.