Enhanced nursing and ganciclovir improve outcomes in paediatric Epstein-Barr Virus infectious mononucleosis: A Randomised Control Trial

Abstract

Objective:To investigate the impact of high-quality nursing interventions and ganciclovir on paediatric Epstein-Barr virus
infectious mononucleosis.
Method: The randomised controlled trial was conducted from March to August 2021 at the Departments of Paediatrics,
Maternal and Child Health Hospital, Tangshan, China, and comprised paediatric patients diagnosed with Epstein-Barr virus
infectious mononucleosis. The patients were randomised into intervention group A receiving high-quality nursing
interventions and ganciclovir, and control group B receiving routine standard care. Primary outcomes included symptom
reduction and laboratory markers, while secondary outcomes included length of hospital stay, time to resolution of
symptoms, adverse events, and patient-reported outcomes. Data was analysed using SPSS 28.
Results: Of the 100 subjects, 50(50%) were in group A; 31(62%) boys and 19(38%) girls with mean age 9.15±1.45 years.
There were 50(50%) patients in group B; 30(60%) boys and 20(40%) girls with mean age 9.15±1.34 years. Group A
demonstrated improvements in outcomes compared to group B (p<0.05).
Conclusion: Ganciclovir and good nursing improved paediatric Epstein-Barr virus infectious mononucleosis treatment.
Keywords: High-quality nursing interventions, Ganciclovir, Epstein-Barr virus, EBV, Infectious mononucleosis.