Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode

Authors

  • Noman Khan Department of Psychiatry, Saidu Group of Teaching Hospital, Swat, Pakistan
  • Usama Bin Zubair Department of Psychiatry, Connoly Hospital, Dublin, Ireland
  • Saad Ali Khan Department of Psychiatry, Fauji Foundation Hospital, Rawalpindi, Pakistan
  • Junaid Ul Islam Department of Psychiatry, Pakistan Institute of Medical Sciences , Islamabad, Pakistan
  • Syed Azhar Ali Kazmi Department of Psychiatry, Poonch Medical College, Rawalkot, Pakistan
  • Abrar Khan Department of Psychiatry, Saidu Group of Teaching Hospital, Swat, Pakistan

DOI:

https://doi.org/10.47391/JPMA.3266

Abstract

This study was conducted to compare the response rate of Quetiapine and Haloperidol in patients with acute manic episodes. A total of 120 patients with acute episode of mania with baseline Young Mania Rating Scale (YMRS) of more than 20 were included and randomly allocated to either Quetiapine (Group A) or Haloperidol (Group B). Each patient was assessed at baseline. YMRS was administered at the start and at follow-up visit after six weeks. Comparison of response rate (>50% reduction in YMRS) was not statistically significant between the two groups (70% vs. 71.7%; p=0.410) after six weeks in acute manic episode. Quetiapine and Haloperidol emerged as equally effective pharmacological strategies for the treatment of bipolar mania. Quetiapine may be used as an alternative to conventional antipsychotics; Haloperidol can be used as replacement of Quetiapine as well, as it is of low cost.

Key Words: Acute manic episode; Quetiapine; Haloperidol

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Published

2022-03-11

How to Cite

Khan, N., Usama Bin Zubair, Saad Ali Khan, Junaid Ul Islam, Syed Azhar Ali Kazmi, & Abrar Khan. (2022). Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode. Journal of the Pakistan Medical Association, 72(8), 1629–1631. https://doi.org/10.47391/JPMA.3266

Issue

Vol. 72 No. 8 (2022): AUGUST

Section

ORIGINAL ARTICLE

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