CNS Manifestations of Rosai-Dorfman Disease

Authors

  • Zanib Javed Section of Neurosurgery, Aga Khan University Hospital, Karachi;
  • Moeez Tariq Department of Surgery, Dr. Ruth KM Pfau Civil Hospital, Dow University of Health Sciences, Karachi-Pakistan
  • Muhammad Shahzad Shamim Section of Neurosurgery, Aga Khan University Hospital, Karachi;

DOI:

https://doi.org/10.47391/JPMA.25-57

Abstract

Rosai-Dorfman disease (RDD) is an abnormal proliferation
of histiocytes which manifest classically as bilateral cervical
lymphadenopathy and B symptoms. Rarely, it also presents
with involvement of other systems. CNS RDD is extremely
rare and accounts for 5% of reported cases. The clinical
picture is dependent on the area of CNS affected. It is
mostly diagnosed on MRI, however, it may be confused
with a meningioma, dural based metastases, lymphoma,
sarcoidosis, etc. Diagnosis is based on typical
histopathological features. The recommended treatment
for symptomatic CNS manifestations of RDD is complete
surgical resection.

Keywords: Rosai-Dorfman disease, Central Nervous
System, Histopathology

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Published

2025-07-01

How to Cite

Zanib Javed, Moeez Tariq, & Muhammad Shahzad Shamim. (2025). CNS Manifestations of Rosai-Dorfman Disease. Journal of the Pakistan Medical Association, 75(07), 1148–1150. https://doi.org/10.47391/JPMA.25-57

Issue

Vol. 75 No. 07 (2025): JULY

Section

EVIDENCE BASED NEURO-ONCOLOGY

License

Copyright (c) 2025 Journal of the Pakistan Medical Association

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This work is licensed under a Creative Commons Attribution 4.0 International License.