The 5C model: Clinical approach to peripheral neuropathy Authors Sanjay Kalra Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, Mohali, India Atul Dhingra Department of Endocrinology, Dr SS Tantai Medical College Hospital & Research Centre, Sriganganagar, India Suneet Kumar Verma Department of Medicine, Alchemist Hospital, Panchkula India; Sparsh Clinic, Panchkula, India Nitin Kapoor Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India; Non communicable disease unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia DOI: https://doi.org/10.47391/JPMA.25-45 Abstract Peripheral neuropathy is a common condition which isoften missed in primary care. The 5C model simplifies theclinical approach to peripheral neuropathy, listing stepsof history taking, physical examination and investigations.One begins by eliciting complaints and concerns, and“classifying by the calendar”. Comorbid and contributorydiseases, concomitant medications and contacted toxins,are then identified. The complications of neuropathy, andthe corrective measures undertaken so far, are explored.This is followed by a physical examination, andsupplemented by investigations. Once the diagnosis isconfirmed, comprehensive management, guided by theLEMON mnemonic, which lists the various facets ofneuropathy care, has to be planned.KEYWORDS: Diabetes, nerve care, neuropathy, nutrition,person centred care, primary care. Downloads Full Text Article Published 2025-06-01 How to Cite Sanjay Kalra, Atul Dhingra, Suneet Kumar Verma, & Nitin Kapoor. (2025). The 5C model: Clinical approach to peripheral neuropathy. Journal of the Pakistan Medical Association, 74(06), 1000–1001. https://doi.org/10.47391/JPMA.25-45 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 06 (2025): JUNE Section PRIMARY CARE DIABETES License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.