Management of high grade primary cerebellar tumours Authors Zanib Javed Department of Surgery, Aga Khan University Hospital, Karachi Pakistan Raheema Sadiq Department of Surgery, Aga Khan University Hospital, Karachi Pakistan Muhammad Shahzad Shamim Department of Surgery, Aga Khan University Hospital, Karachi Pakistan DOI: https://doi.org/10.47391/JPMA.24-92 Abstract Cerebellar high-grade gliomas (cHGG) are uncommon inadults, making up only about 1% of all high-grade gliomas.These tumours differ from supratentorial high-gradegliomas (sHGG) in terms of epidemiology, molecular traits,and the age of the patients. cHGG patients are typicallyyounger and show a higher frequency ofneurofibromatosis 1 (NF1) mutations, atypical RASmutations, and H3K27M mutations. Standard treatmentincludes surgical resection followed by chemotherapy andradiation. Recent studies emphasize the genetic differencesbetween cerebellar and supratentorial tumours, with newtreatments targetting specific molecular abnormalities.Immunotherapy has shown limited effectiveness due tothe unique tumour environment in cHGG, and furtherresearch is required to improve treatment strategies forthese rare tumours.Keywords: Cerebellar glioma, high-grade glioma,molecular therapies, immunotherapy. Downloads Full Text Article Published 2024-10-16 How to Cite Zanib Javed, Raheema Sadiq, & Muhammad Shahzad Shamim. (2024). Management of high grade primary cerebellar tumours. Journal of the Pakistan Medical Association, 74(11), 2018–2020. https://doi.org/10.47391/JPMA.24-92 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 11 (2024): NOVEMBER Section EVIDENCE BASED NEURO-ONCOLOGY License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.