Hydroxyapatite, a potent agent to reduce dentin hypersensitivity; systematic review Authors Hashmat Gul Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan Muhammad Asad Ghaffar Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan Muhammad Kaleem Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan Abdul Samad Khan Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia DOI: https://doi.org/10.47391/JPMA.01175 Abstract Objective: This study reviews different modes of application of hydroxyapatite for treatment of dentin hypersensitivity via dentinal tubule occlusion. Methods: Literature search was performed using keywords, “hydroxyapatite and dentin hypersensitivity, hydroxyapatite and dentinal tubule occlusion, hydroxyapatite and dentin permeability, dentinal tubule occlusion” on Pubmed, Science Direct and Web of Science, which involved the results of previous 10 years (2009-2018). After screening, 16 studies were included in systematic review. Results: The results of in-vitro studies showed that application of hydroxyapatite caused dentinal tubule occlusion leading to reduction in dentin permeability and reduction in dentin hypersensitivity. Conclusion: Hydroxyapatite has the potential to reduce dentin hypersensitivity via dentinal tubule occlusion within 2-8 weeks. Keywords: Dentin hypersensitivity, Hydroxyapatite, Dentinal tubule occlusion. Continuous... Downloads Full Text Article Published 2021-11-29 How to Cite Gul , H. ., Muhammad Asad Ghaffar, Muhammad Kaleem, & Abdul Samad Khan. (2021). Hydroxyapatite, a potent agent to reduce dentin hypersensitivity; systematic review. Journal of the Pakistan Medical Association, 71(11), 2604–2610. https://doi.org/10.47391/JPMA.01175 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 71 No. 11 (2021): NOVEMBER Section SYSTEMATIC REVIEWS