Osmolar gap in hyponatraemia—an exploratory study Authors Shoukat Memon Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan https://orcid.org/0000-0002-1894-1963 Faiza Saeed Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan Ashar Alam Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan Javeria Chughtai Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan Salman Imtiaz Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.10483 Keywords: Hyponatremia, Osmolality, mortality, Osmolar gap (OG) Abstract Hyponatraemia has indeed been extensively studied from multiple angles, including volume status, tonicity, and aetiology; however, the specific consideration of the osmolar gap (OG) within the context of hyponatraemia and its potential impact on their overall outcomes received limited attention in research. The current study represents an effort to address this gap in our understanding. This prospective exploratory study was conducted on adults aged 14 years and older at the Indus Hospital, Karachi, from 2017 to 2020. The study involved categorising severity of hyponatraemia and volume status. The osmolar gap (OG) was calculated and categorised as either increased (OG>10) or normal (OG<10). Among the 262 patients included in the study, there were 139 females and 123 males. Elevated OG was observed in 141(53.8%) patients. There were 28 (10.7%) recorded fatalities and majority of these individuals had an elevated OG. ---Continue Author Biographies Faiza Saeed, Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan Consultant, Nephrology department Javeria Chughtai, Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan Senior Registrar Salman Imtiaz, Department of Nephrology, Indus Hospital and Health Network, Karachi, Pakistan Professor and Head of Department Downloads Full Text Article Published 2024-05-24 How to Cite Memon, S., Saeed, F., Alam, A., Chughtai, J., & Imtiaz, S. (2024). Osmolar gap in hyponatraemia—an exploratory study. Journal of the Pakistan Medical Association, 74(6), 1163–1166. https://doi.org/10.47391/JPMA.10483 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 6 (2024): JUNE Section SHORT COMMUNICATION License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.