Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence Authors Lizhi Zhou Comprehensive Department, Traditional Chinese Medicine Rehabilitation, China Xuying Li Department of Traditional Chinese Medicine, Shiyan Taihe Hospital Affiliated to Hubei University of Medicine, China Jinbi Ao Orthopaedic Rehabilitation Center, Wudangshan Hospital, Shiyan Taihe Hospital Affiliated to Hubei University of Medicine, China Na Duan Department of Obstetrics, Shiyan Taihe Hospital Affiliated to Hubei University of Medicine, China DOI: https://doi.org/10.47391/JPMA.10423 Keywords: Acupuncture therapy, Autophagy, Forkhead transcription factor O, Transcription factors, Cellular senescence, Aging, Traditional Chinese medicine Abstract The current narrative review was planned to elucidate the interplay between acupuncture, a cornerstone of Traditional Chinese Medicine, and the modulation of cellular mechanisms via Forkhead box O transcription factors, focussing on autophagy and cellular senescence. Autophagy, essential for cellular health, and cellular senescence, associated with aging and age-related diseases, are both significantly influenced by Forkhead box O transcription factors among other regulatory factors and pathways. These factors, known to diminish with age, play a pivotal role in promoting longevity. The current review analysed experimental models demonstrating acupuncture's capacity to activate Forkhead box O transcription factors, thereby inducing autophagy and reducing cellular senescence. Evidence from studies on human fibroblasts, aging animal models, obesity-induced insulin resistance, and osteoporosis corroborates the beneficial effects of acupuncture. ---Continue Downloads Full Text Article Published 2024-11-17 How to Cite Zhou, L., Li, X., Ao, J., & Duan, N. (2024). Acupuncture and cellular mechanisms: the role of foxo transcription factors in autophagy and senescence. Journal of the Pakistan Medical Association, 74(12), 2150–2154. https://doi.org/10.47391/JPMA.10423 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 12 (2024): DECEMBER Section Narrative Review License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.