Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio Authors Sana Akhlaq Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan. Saba Khaliq Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan. DOI: https://doi.org/10.47391/JPMA.10405 Keywords: Wnt signalling pathway, Frizzled related protein 4, Diabetes mellitus, Type 2, Insulin resistance, Waist-height ratio, Blood glucose, Insulin, Waist circumference, Mass screening, Cross-sectional studies, Family, NAFLD, Metabolic syndrome Abstract The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional comparative study comprised 80 subjects with confirmed normal glucose tolerance values. Parameters assessed included secreted frizzled related protein-4, fasting glucose, random glucose, fasting insulin, homeostasis model of assessment of insulin resistance and waist-to-height ratio values. Those without a diabetic background had significantly higher frizzled related protein-4 levels (p=0.02). Although subjects with family history of diabetes showed higher mean fasting glucose, waist circumference and waist-to-height ratio, these differences were not statistically significant (p>0.05). However, there was a strong positive correlation with waist circumference, waist-to-height ratio, fasting insulin and homeostasis model of assessment of insulin resistance (p=0.0001). ---Continue Author Biography Saba Khaliq, Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan. Supervisor Downloads Full Text Article Published 2024-06-28 How to Cite Sana Akhlaq, & Saba Khaliq. (2024). Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio. Journal of the Pakistan Medical Association, 74(7), 1338–1341. https://doi.org/10.47391/JPMA.10405 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 7 (2024): JULY Section SHORT REPORT License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.