Anti-AMPA receptor encephalitis with myasthenia gravis: a sinister combination associated with a high risk for underlying malignancy Authors Tahira Mohammad Department of Immunology, Shifa International Hospital, Islamabad, Pakistan Muhammad Ali Yousaf Department of Neurology, Combined Military Hospital, Lahore, Pakistan Momina Qaisar Department of Neurology, Combined Military Hospital, Lahore, Pakistan Farva Jalil Department of Immunology, Shifa International Hospital, Islamabad, Pakistan Tahir Aziz Ahmed Department of Immunology, Shifa International Hospital, Islamabad, Pakistan DOI: https://doi.org/10.47391/JPMA.10397 Keywords: Autoimmune encephalitis, Limbic encephalitis, AMPA receptor encephalitis, Anti-acetylcholine receptor antibodies, Case report Abstract A rare subtype of autoimmune encephalitis consists of antibodies targeting the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor in the central nervous system. We describe the clinical presentation and autoimmune profile of the first case of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis with concurrent anti-acetylcholine receptor antibodies in Pakistan. The patient was a 58-year-old male who presented with the characteristic symptoms of limbic encephalitis with memory loss, irritability, agitation, and confusion. Antibodies against the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor were detected in both serum and cerebrospinal fluid by indirect immunofluorescence. Computerised tomography of the chest showed an anterior mediastinal mass. The patient was treated with high dose Methylprednisolone and five sessions of plasma exchange. There was a short period of improvement; however, the patient now continues to exhibit irritability, aphasia, confusion, and memory loss. ---Continue Downloads Full Text Article Published 2024-07-25 How to Cite Mohammad, T., Yousaf, M. A., Qaisar, M., Jalil, F., & Ahmed, T. A. (2024). Anti-AMPA receptor encephalitis with myasthenia gravis: a sinister combination associated with a high risk for underlying malignancy. Journal of the Pakistan Medical Association, 74(8), 1514–1517. https://doi.org/10.47391/JPMA.10397 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 8 (2024): AUGUST Section CASE REPORT License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.