To evaluate the role of interleukin-6 in alopecia areata Authors Sobia Wali Muhammad Department of Medical Research Centre, Liaquat University of Health Sciences, Jamshoro, Pakistan Muhammad Suleman Pirzado Department of Molecular Biology and Genetics Laboratory, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan DOI: https://doi.org/10.47391/JPMA.10284 Keywords: Alopecia areata, Autoimmune, Cytokines, Interleukin-6, Skin disease Abstract Objective: To investigate the level of interleukin-6 in alopecia areata patients. Method: The exploratory study was conducted from September to December 2021 at the Sindh Institute of Skin Disease, Karachi, and comprised alopecia areata patients regardless of age and gender in group A, while healthy controls matched for age and gender formed group B. Alopecia areata classification and severity were done using the Severity of Alopecia Tool. Serum interleukin-6 was measured using enzyme-linked immune sorbent assay. Data was analysed using R statistical software v4.2.1. Results: Of the 100 subjects, 50(50%) with mean age 15.52+/-10.14 years were cases in group A; 26(52%) females with mean age 16.78±10.77 years, and 24(48%) males with mean age 16.44±10.3 years. The remaining 50(50%) were controls in group B. Interleukin-6 concentration was significantly higher in group A (p<0.05). The concentration was not significantly different between the genders (p>0.05). The concentration was the highest in patients aged 11-20 years, followed by 21-30 years, 31-40 years and 1-10 years. Conclusion: The concentration of circulatory pro-inflammatory interleukin-6 was significantly higher in alopecia areata patients than in the healthy controls. Key Words: Alopecia areata, Autoimmune, Cytokines, Interleukin-6, Skin disease. Downloads Full Text Article Published 2024-04-22 How to Cite Wali Muhammad, S., & Pirzado, M. S. (2024). To evaluate the role of interleukin-6 in alopecia areata. Journal of the Pakistan Medical Association, 74(5), 930–933. https://doi.org/10.47391/JPMA.10284 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 5 (2024): MAY Section RESEARCH ARTICLE License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.