68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas

Authors

  • Sharjeel Usmani Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman
  • Anjali Jain Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman.
  • Syed Furqan Hashmi Radiation Oncology, Sultan Qaboos Comprehensive Cancer Care and Research center (SQCCCRC), Muscat Oman.
  • Layth Mula-Hussain Radiation Oncology, Sultan Qaboos Comprehensive Cancer Care and Research center (SQCCCRC), Muscat Oman
  • Khulood Al Riyami Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman
  • Sofiullah Abubakar Department of Nuclear Medicine, Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC), Muscat Oman.
  • Muhammad Shahzad Shamim Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi.

DOI:

https://doi.org/10.47391/JPMA.23-44

Keywords:

68Ga-DOTA PET/CT, Meningioma, 177Lu-DOTATATE, PET/CT, radiotherapy planning

Abstract

Meningiomas overexpress somatostatin receptors (SSTR). PET imaging with SSTR ligands such as 68Ga-DOTA-peptide has recently shown high diagnostic accuracy in identification of meningiomas due to lack of normal bone and brain activity. PET-derived parameters, especially gross tumour volume (GTV) delineation improves inter-observer variability and appears to be particularly promising for RT planning. The potential strength of 68Ga-DOTA in the ongoing assessment of treatment response and disease progression in meningioma, particularly in the post-surgical and post-radiation settings is encouraging. More prospective randomized studies with large cohorts of patients are required to define the effective role of this modality.

Keywords: 68Ga-DOTA PET/CT; Meningioma; 177Lu-DOTATATE; PET/CT; radiotherapy planning.

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Published

2023-05-15

How to Cite

Sharjeel Usmani, Anjali Jain, Syed Furqan Hashmi, Layth Mula-Hussain, Khulood Al Riyami, Sofiullah Abubakar, & Muhammad Shahzad Shamim. (2023). 68Ga-DOTA-peptide PET/CT for radiotherapy planning and evaluating treatment response in the management of meningiomas. Journal of the Pakistan Medical Association, 73(6), 1340–1343. https://doi.org/10.47391/JPMA.23-44

Issue

Vol. 73 No. 6 (2023): JUNE

Section

EVIDENCE BASED NEURO-ONCOLOGY

License

Copyright (c) 2023 Journal of the Pakistan Medical Association

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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