The prognostic relevance of 14-3-3 expression in cancers: a meta-analysis

Authors

  • Caihong Li Department of Respiratory, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
  • Honglan Zhu Department of Respiratory, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
  • Changlu Liu Department of Respiratory, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
  • Ya Liu Department of Respiratory, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
  • Ting Huang Department of Respiratory, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China
  • Daishun Liu Department of Respiratory, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China

DOI:

https://doi.org/10.47391/JPMA.03-402

Abstract

Objective: A number of recent clinical studies have identified a relationship between elevated expressions of 14-3-3 and poorer patient prognosis in the context of several cancers. The present meta-analysis was therefore conducted to gain an enhanced understanding of the prognostic importance of 14-3-3 levels in cancer patients.
Methods: Two reviewers independently systematically reviewed the Web of Science, Embase, and PubMed databases to identify published, suitable studies through October 2019. The correlation between the level of 14-3-3 and cancer patient survival were assessed based upon pooled HR (hazard ratios) and 95% CI (confidence intervals) derived from chosen studies.
Results: In total we were able to identify 22 eligible studies that had enrolled 2676 patients in the present meta-analysis. Assessment of these studies revealed that elevated 14-3-3 level correlated significantly with poorer OS (overall survival) (HR : 1.93, 95% CI : 1.42-2.61) in cancer patients. This was true even when studies were analyzed in subgroups according to tumor type, sample size, analysis type, and method of HR determination. With respect to disease-free survival (DFS), the pooled HR for cancer patients expressing high levels of 14-3-3 was 1.89 (95% CI: 1.56-2.30). Patients with elevated 14-3-3 expression also exhibited reduced CSS (cancer-specific survival) (HR: 3.47, 95% CI: 2.12-5.69).
Conclusions: The outcomes indicate that higher level of 14-3-3 correlates with poorer patient prognosis in a range of cancer types.
Keywords: Meta-analysis, Prognosis, 14-3-3 Proteins C

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Published

2021-11-01

How to Cite

Caihong Li, Honglan Zhu, Changlu Liu, Ya Liu, Ting Huang, & Daishun Liu. (2021). The prognostic relevance of 14-3-3 expression in cancers: a meta-analysis. Journal of the Pakistan Medical Association, 71(4), 1206–1213. https://doi.org/10.47391/JPMA.03-402

Issue

Vol. 71 No. 4 (2021): APRIL

Section

META-ANALYSIS