December 1985, Volume 35, Issue 12

Editorial

MECHANISMS OF RESISTANCE TO METHOTREXATE

M. Perwaiz Iqbal

Methotrexate (MTX) is a folate antagonist which kills the proliferating cell by binding tightly to the enzyme dihydrofolate reductase (DHFR). Due to this binding the pathway of de novo DNA synthesis is blocked1-3. The drug has produced spectacular results co

RESEARCH ARTICLES

IN THIS ISSUE

Minor Procedures In Surgery

VENESECTION INTRAVENOUS CATHETERISATION

Rizwan Azami , et al

REVIEW ARTICLES

Journal of the Pakistan Medical Association has agreed to receive and publish manuscripts in accordance with the principles of the following committees: