Mesenteric panniculitis associated with non-alcoholic fatty liver disease: a case series

Authors

  • Mehreen Siyal Department of Gastroenterology and Hepatology, Dr. Ziauddin Hospital, Karachi, Pakistan
  • Zaigham Abbas Department of Gastroenterology and Hepatology, Dr. Ziauddin Hospital, Karachi, Pakistan
  • Alina Saeed Department of Gastroenterology and Hepatology, Dr. Ziauddin Hospital, Karachi, Pakistan
  • Muhammad Ali Qadeer Department of Gastroenterology and Hepatology, Dr. Ziauddin Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.9643

Keywords:

Mesenteric panniculitis, Non-alcoholic steatohepatitis, steatohepatitis, Dyslipidaemia, Insulin resistance

Abstract

Mesenteric panniculitis (MP) is a benign inflammatory condition of the abdominal mesentery which presents with a wide variety of symptoms. It is diagnosed non-invasively through computed tomography (CT) scan, whereas biopsy is still considered the gold standard. Steroids are the first line of treatment. Here, we report four cases who presented with abdominal pain. These patients were overweight and the CT scan findings were suggestive of mesenteric panniculitis. Three cases had concomitant non-alcoholic steatohepatitis with elevated alanine transaminase levels, dyslipidaemia, and insulin resistance. FibroScan showed moderate to severe steatosis. PNPLA3 rs738409 genotype was homozygous positive (GG) in one patient, whereas two patients were heterozygous positive (CG). This association has not been well-described so far and warrants further investigation. There may be some common predisposing factors.

Key words: Mesenteric panniculitis, Non-alcoholic steatohepatitis, Dyslipidaemia, Insulin resistance.

Published

2024-04-22

How to Cite

Siyal, M., Abbas, Z., Saeed, A., & Qadeer, M. A. (2024). Mesenteric panniculitis associated with non-alcoholic fatty liver disease: a case series. Journal of the Pakistan Medical Association, 74(5), 993–997. https://doi.org/10.47391/JPMA.9643

Issue

Section

CASE SERIES

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