Nimesulide: A double-edged sword must be banned

Authors

  • Muhammad Moaz Bin Khalid Department of Orthopedics, Services Hospital, Lahore, Pakistan
  • Muhammad Nouman Department of General Surgery, Services Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.47391/JPMA.9593

Abstract

Dear Editor,

My purpose in writing this letter is to draw your attention to a very susceptible situation of possible adverse reactions like hepatotoxicity caused by Nimesulide. It is being prescribed as an over-the-counter drug and is available even online for home delivery without any prescription in Pakistan.

Nimesulide is an atypical selective COX-2 inhibitor that is similar in anti-inflammatory effects as compared to other classical NSAIDs and selective COX-2 (celecoxib & rofecoxib) inhibitors but different as it has a protective effect on NSAID-induced ulcers as compared to other more selective COX-2 inhibitors, which do prevent but do not protect NSAID induced ulcers.

But, does this only benefit of being gastroprotective justify its use as a relatively common drug with or without a prescription?

---Continue

Published

2023-11-28

How to Cite

Bin Khalid, M. M., & Muhammad Nouman. (2023). Nimesulide: A double-edged sword must be banned. Journal of the Pakistan Medical Association, 73(12), 2511–2511. https://doi.org/10.47391/JPMA.9593

Issue

Section

LETTER TO THE EDITOR