Nimesulide: A double-edged sword must be banned Authors Muhammad Moaz Bin Khalid Department of Orthopedics, Services Hospital, Lahore, Pakistan Muhammad Nouman Department of General Surgery, Services Hospital, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.9593 Abstract Dear Editor, My purpose in writing this letter is to draw your attention to a very susceptible situation of possible adverse reactions like hepatotoxicity caused by Nimesulide. It is being prescribed as an over-the-counter drug and is available even online for home delivery without any prescription in Pakistan. Nimesulide is an atypical selective COX-2 inhibitor that is similar in anti-inflammatory effects as compared to other classical NSAIDs and selective COX-2 (celecoxib & rofecoxib) inhibitors but different as it has a protective effect on NSAID-induced ulcers as compared to other more selective COX-2 inhibitors, which do prevent but do not protect NSAID induced ulcers. But, does this only benefit of being gastroprotective justify its use as a relatively common drug with or without a prescription? ---Continue Downloads Full Text Article Published 2023-11-28 How to Cite Bin Khalid, M. M., & Muhammad Nouman. (2023). Nimesulide: A double-edged sword must be banned. Journal of the Pakistan Medical Association, 73(12), 2511–2511. https://doi.org/10.47391/JPMA.9593 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 12 (2023): DECEMBER Section LETTER TO THE EDITOR License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.