Long-term proton pump inhibitors therapy and prevalence of hyperprolactinemia. a cross-sectional study in outpatient gastroenterology clinics Authors Muhammad Ashfaq Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan Adil Naseer Khan Department of Gastroenterology, MTI Ayub Medical Complex, Abbottabad, Pakistan Yasser MSA Alkahraman Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan Muhammad Zeeshan Haroon Department of Community Medicine, Ayub Medical College, Abbottabad, Pakistan DOI: https://doi.org/10.47391/JPMA.9541 Keywords: Proton pump inhibitors, Long-term therapy, Hyperprolactinemia, Omeprazole, Prolactin Abstract Objective: To evaluate serum prolactin and macroprolactin levels in patients on long-term proton pump inhibitors therapy. Method: The cross-sectional study was conducted from January 2018 to November 2019 after approval from the ethics review committee of the Commission on Science and Technology for Sustainable Development in the South University, Abbottabad, Pakistan. And comprised patients from two gastroenterology outpatient clinics in the Khyber Pakhtunkhwa province using proton pump inhibitors for >3 months either alone or in combination with either histamine receptor antagonists or prokinetics. Blood samples were collected from each patient for hormonal screening. Data was analysed using SPSS 25. Results: Of the 166 patients, 101(60.8%) were females and 65(39.2%) were males. The overall mean age was 42.5±14.2 years, and the median serum prolactin level was 23.2ng/ml (interquartile range: 14.0-38.0ng/ml). There were 96(58%) patients with normoprolactinemia and 70(42%) with hypreprolactinemia. There were 19(11.4%) patients using combination therapy, while the rest were on proton pump inhibitors monotherapy. There was a significant increase in serum prolactin level with combination therapy compared to monotherapy (p=0.001). Pateints having treatment duration 11-20 months (p=0.006) and >40 months (p=0.001) were at high risk of developing hyperprolactinemia. Conclusion: Long-term use of proton pump inhibitors could increase serum prolactin levels, and appropriate evaluation is essential for clinical management. Key Words: Proton pump inhibitors, Long-term therapy, Hyperprolactinemia, Omeprazole, Prolactin. Author Biographies Muhammad Ashfaq, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan Adil Naseer Khan, Department of Gastroenterology, MTI Ayub Medical Complex, Abbottabad, Pakistan Head of Gastroenterology Unit, MTI Ayub Medical Complex, Abbottabad, Pakistan Yasser MSA Alkahraman, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan Downloads Full Text Article Published 2024-05-24 How to Cite Ashfaq, M., Khan, A. N., Alkahraman, Y. M., & Haroon, M. Z. (2024). Long-term proton pump inhibitors therapy and prevalence of hyperprolactinemia. a cross-sectional study in outpatient gastroenterology clinics. Journal of the Pakistan Medical Association, 74(6), 1067–1073. https://doi.org/10.47391/JPMA.9541 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 6 (2024): JUNE Section RESEARCH ARTICLE License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.