Common variable immunodeficiency associated enteropathy: a diagnostic enigma in developing countries Authors Muhammad Aftab Hassan Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan Muhammad Hussain Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan Dawood Ahmad Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan Muhammad Omair Riaz Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan Muhammad Zain Arshad Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan DOI: https://doi.org/10.47391/JPMA.9376 Keywords: Common Variable Immunodeficiency, Enteropathy, Primary Immunodeficiency Abstract Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency disorder with different phenotypes and aetiologies. It is characterised by hypogammaglobulinaemia, defects in specific antibody response, erroneous activation and proliferation of T cells, leading to increased risk of recurrent infections. In CVID, "Variable" refers to the heterogeneity of clinical presentations, which include recurrent infections, autoimmunity, enteropathy, and increased risk of malignancies. This wide spectrum of disease manifestations and being a diagnosis of exclusion poses a diagnostic challenge. It is pertinent to mention that CVID along with associated complications is the commonest symptomatic primary antibody deficiency but is scarcely mentioned in local literature. The main aim of presenting this case is to impress upon the importance of systematic immunological workup in cases of suspected immunodeficiency to prevent morbidity and mortality. Key words: Common Variable Immunodeficiency, Enteropathy, Primary Immunodeficiency. Downloads Full Text Article Published 2024-05-24 How to Cite Hassan, M. A., Muhammad Hussain, Dawood Ahmad, Muhammad Omair Riaz, & Muhammad Zain Arshad. (2024). Common variable immunodeficiency associated enteropathy: a diagnostic enigma in developing countries. Journal of the Pakistan Medical Association, 74(6), 1175–1177. https://doi.org/10.47391/JPMA.9376 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 6 (2024): JUNE Section Case Report License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.