Kasabach-Merritt Syndrome: a case study of successful treatment with vincristine and propranolol Authors Aqsa Mazhar Vascular Anomalies Center, Indus Hospital and Health Network, Karachi, Pakistan https://orcid.org/0000-0002-6812-7046 Afza Naureen Ghouse Department of Dermatology, The Indus Hospital, Karachi, Pakistan Saba Shahid Department of Pediatric Medicine, The Indus Hospital, Karachi, Pakistan Lubna Samad Interactive Research and Development (IRD), Global, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.9185 Keywords: Kasabach-Merritt syndrome, Haemangioma, Thrombocytopenia Abstract Kasabach-Merritt syndrome is a rare condition, characterised by the presence of an enlarging vascular tumour associated with thrombocytopenia, microangiopathic haemolytic anaemia and consumptive coagulopathy. The syndrome manifests in infancy, with high morbidity and mortality rates. No standard guidelines have been established for the treatment of Kasabach-Merritt syndrome to date. To existing literature we add this report of a four-month-old female child with Kasabach-Merritt syndrome who was successfully treated with propranolol and vincristine. This drug combination helped reverse the severe thrombocytopenia as well as decrease in size of her haemangioma. Management of Kasabach-Merritt syndrome continues to be a challenge, with varying response to first line drugs. Early diagnosis and initiation of treatment in a closely monitored setting is essential to ensure good outcomes. Since this is a relatively rare condition and large studies are not feasible, documenting treatment experience for single cases or small series becomes even more important. Downloads Full Text Article Published 2023-11-28 How to Cite Mazhar, A., Ghouse, A. N., Shahid, S., & Lubna Samad. (2023). Kasabach-Merritt Syndrome: a case study of successful treatment with vincristine and propranolol. Journal of the Pakistan Medical Association, 73(12), 2476–2479. https://doi.org/10.47391/JPMA.9185 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 12 (2023): DECEMBER Section CASE REPORT License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.