The promise of stem cells in amyotrophic lateral sclerosis: a review of clinical trials Authors Muhammad Usman Khalid Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan. Taleaa Masroor Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan. DOI: https://doi.org/10.47391/JPMA.AKUS-22 Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition with high cost of care, poor treatment outcomes, and a significant decrease in quality of life, eventually culminating in high mortality rates. Stem cells present an attractive alternative to conventional therapies as they can regenerate tissue and introduce growth factors to slow down the progression of disease. We conducted a comprehensive review of literature available in the MEDLINE (PUBMED), Scopus, and Cochrane Library databases, of current usage of stem cells and stem cell-based biomaterials for ALS treatment. Clinical trials, less than 10 years old, on human subjects were included in the study. Overall, stem cells, whether mesenchymal, non-lineage, or neural stem cells all seem safe for use in therapy for ALS. However, due to the chronic nature of the disease the efficacy of the treatment is not proven and warrants further investigation. Keywords: Amyotrophic Lateral Sclerosis. Biocompatible Materials, Neural, Stem Cells Downloads Full Text Article Published 2023-01-25 How to Cite Muhammad Usman Khalid, & Taleaa Masroor. (2023). The promise of stem cells in amyotrophic lateral sclerosis: a review of clinical trials. Journal of the Pakistan Medical Association, 73(2), S138-S142. https://doi.org/10.47391/JPMA.AKUS-22 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 2 (2023): Stem Cells: A New Frontier in Surgery Section Review Article