An insight into genetic landscape of inflammatory bowel disease Authors Zunaira Ali Baig Department of Biochemistry and Molecular Biology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan Asifa Majeed Department of Biochemistry and Molecular Biology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan DOI: https://doi.org/10.47391/JPMA.9050 Keywords: Crohn’s disease, Gut microbiota, Inflammatory bowel disease Abstract Inflammatory bowel disease has been regarded to be chronic intestinal inflammation characterised by a dsyregulatory immune response. The disease pathophysiology is known to be complex. Growing pieces of evidences underpin the involvement of various environmental and genetic determinants in the disease onset. The current narrative review was planned to manifest the contribution of genetic drivers for disease onset and to target signalling pathways that might present a therapeutic potential for further research. The factors of the disease that provide the genetic nature and understanding of the pathways involved have been researched in recent times. Also, numerous disease-developing factors have been studied and assessed. Among them genetic determinants of disease onset have further improved the understanding of disease development. Genetic contributors to the onset of disease as well as important therapeutic targets need to be understood as predictive genetic risk factors have a potential implication for personalised treatment. Downloads Full Text Article Published 2023-11-28 How to Cite Baig, Z. A., & Majeed, A. (2023). An insight into genetic landscape of inflammatory bowel disease. Journal of the Pakistan Medical Association, 73(12), 2415–2422. https://doi.org/10.47391/JPMA.9050 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 12 (2023): DECEMBER Section NARRATIVE REVIEW License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.