Irisin; a myokine with therapeutic and diagnostic potential in clinical dentistry Authors Alina Saleem Department of Oral Biology, University of Health Sciences, Lahore, Pakistan Sarah Ghafoor Department of Oral Biology, University of Health Sciences, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.8360 Keywords: FNDC5, Irisin, Human periodontal ligament cell, Human dental pulp stem cell, Bone, Regeneration Abstract Irisin is a novel adipomyokine which has extensive systemic and local effects in different tissues of the body. The scientific interest in understanding the physiological roles of irisin in the body has increased tremendously in the past few years due to its vast therapeutic potential in different fields of medicine. The current narrative review was planned to describe the molecular mechanisms by which irisin regulates oral hard and soft tissues. The information gleaned provided useful insights for future researchers to investigate newly discovered roles of irisin in craniofacial health and disease, and to explore the potential of irisin as a promising therapeutic and diagnostic agent in clinical dentistry. Key Words: FNDC5, Irisin, Human periodontal ligament cell, Human dental pulp stem cell, Bone, Regeneration. Downloads Full Text Article Published 2023-10-30 How to Cite Saleem, A., & Sarah Ghafoor. (2023). Irisin; a myokine with therapeutic and diagnostic potential in clinical dentistry. Journal of the Pakistan Medical Association, 73(11), 2214–2218. https://doi.org/10.47391/JPMA.8360 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 11 (2023): NOVEMBER Section Narrative Review License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.