Wernicke’s encephalopathy secondary to hyperemesis gravidarum: a clinical challenge Authors Tooba Mehreen Department of Critical Care, Shifa International Hospital, Islamabad, Pakistan Sara Saghir Kiani Department of Internal Medicine, Shifa International Hospital, Islamabad, Pakistan DOI: https://doi.org/10.47391/JPMA.0814 Abstract Wernicke’s encephalopathy (WE) is an acute neurological condition characterized by a triad of ophthalmoplegia, ataxia and altered mental status. The underlying cause is thiamine deficiency, which may be due to multiple aetiologies. Thiamine is essential for carbohydrate and amino acid metabolism. Its deficiency shunts glucose to anaerobic pathways producing metabolic abnormalities. Diagnosing WE relies heavily on clinical suspicion. Magnetic Resonance Imaging can show some specific findings. We report this case of a 35 year old pregnant woman with gestational diabetes who was admitted in hospital for high blood sugar levels and electrolyte abnormalities. She had a history of ten miscarriages. From undergoing laparoscopic cholecystectomy for intractable vomiting to spontaneous expulsion of the foetus to being intubated for acidosis, her hospital stay was prolonged and eventful. Although the cause of her repeated miscarriages could not be established despite extensive workup, Continues... Published 2022-02-03 How to Cite Tooba Mehreen, & Sara Saghir Kiani. (2022). Wernicke’s encephalopathy secondary to hyperemesis gravidarum: a clinical challenge. Journal of the Pakistan Medical Association, 72(3). https://doi.org/10.47391/JPMA.0814 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 3 (2022): MARCH Section CASE REPORT