The role of single-cell RNA sequencing in cardiac tumour - a case report Authors Xian-Jie Qi The First Affiliated Hospital of Bengbu Medical College, Bengbu, China Ting Wei The First Affiliated Hospital of Bengbu Medical College, Bengbu, China Isah Amir Abba The First Affiliated Hospital of Bengbu Medical College, Bengbu, China Sheng-Qiang Zhang Department of Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China Jin-jin Meng Department of Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China Chao Shi Department of Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China Yiyao Jiang Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China DOI: https://doi.org/10.47391/JPMA.7776 Keywords: Sequence Analysis, RNA, Cardiac tumour Abstract A 65-year-old woman presented to our hospital with 5 days of chest tightness, dyspnoea, and lower abdominal distension. Echocardiography revealed a mass in the right atrium. An emergency operation was carried out to prevent tumour shedding. The patient was discharged on the 4th day of tumour resection, without any complications At the 18 months follow-up, she suffered from kidney and lung tumours. She refused any treatment and passed away. scRNA-seq was applied to analyse the nature of the tumour. The cellular components of benign tumours include chondrocytes, smooth muscle cells, fibroblasts, mesenchymal stromal cells, and osteoblasts. Additionally, the cyclic guanosine monophosphate (cGMP-PKG) signalling pathway, transcriptional misregulation in cancer, and the p53 signalling pathway may be related to the growth of this tumour. scRNA-seq is a good approach to analyse growth patterns of cardiac tumours and helpful for distinguishing the nature of the tumour. Keywords: Sequence Analysis, RNA, Cardiac tumour. Downloads Full Text Article Published 2023-11-28 How to Cite Qi, X.-J., Wei, T., Abba, I. A., Zhang, S.-Q., Meng, J.- jin, Shi, C., & Jiang, Y. (2023). The role of single-cell RNA sequencing in cardiac tumour - a case report. Journal of the Pakistan Medical Association, 73(12), 2462–2464. https://doi.org/10.47391/JPMA.7776 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 12 (2023): DECEMBER Section CASE REPORT License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.