Clinical outcomes and predictors of mortality in COVID-19 patients admitted to a High Dependency Unit in Pakistan-a cross-sectional study

Authors

  • Samar Fatima Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
  • Sara Shamim Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
  • Taymmia Ejaz Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.7288

Keywords:

COVID-19, In-hospital mortality, Multimorbidity, SARS-CoV-2 infection, Critical care outcomes

Abstract

Objective: To determine the outcomes and predictors of in-hospital mortality of patients admitted to high-dependency unit with coronavirus disease 2019 infection.

Method: The retrospective study was conducted at a tertiary care hospital in Karachi, and comprised data of adult coronavirus disease 2019 patients of either gender admitted to the high dependency unit from March 1 to June 30, 2020. Outcomes were categorised as patients ‘recovered without deterioration’, ‘deteriorated but survived’, and ‘deteriorated but expired’. Data was analysed using SPSS 22.

Results: Of the 525 patients with confirmed infection, 245(46.6%) were admitted to the high dependency unit. Leaving out 38(15.5%) cases with missing data, 207(84.5%) cases formed the study sample; 156(75.4%) males and 51(24.6%) females. The overall mean age was 56.9±14years (range: 24-86 years). The most common comorbid condition was hypertension 105(50.7%), and the most common reason for critical care was hypoxic respiratory failure 199(96.1%). Of the total, 153(74%) patients recovered, 31(15%) deteriorated, and mortality was the outcome in 23(11%). There was no significant effect of drug treatment on mortality (p>0.05). Age, multimorbidity and high D-Dimer level were significantly associated with disease progression and mortality (p<0.05).

Conclusion: Mortality was high among coronavirus disease 2019 patients who were older and had multimorbidity.

Key Words: COVID-19, In-hospital mortality, Multimorbidity, SARS-CoV-2 infection, Critical care outcomes.

Author Biography

Samar Fatima, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan

Section of Internal Medicine,Department of Medicine

Published

2023-07-15

How to Cite

Fatima, S., Shamim, S., & Ejaz, T. (2023). Clinical outcomes and predictors of mortality in COVID-19 patients admitted to a High Dependency Unit in Pakistan-a cross-sectional study. Journal of the Pakistan Medical Association, 73(8), 1628–1633. https://doi.org/10.47391/JPMA.7288

Issue

Section

RESEARCH ARTICLE

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