Clinical outcomes and predictors of mortality in COVID-19 patients admitted to a High Dependency Unit in Pakistan-a cross-sectional study Authors Samar Fatima Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan Sara Shamim Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan Taymmia Ejaz Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.7288 Keywords: COVID-19, In-hospital mortality, Multimorbidity, SARS-CoV-2 infection, Critical care outcomes Abstract Objective: To determine the outcomes and predictors of in-hospital mortality of patients admitted to high-dependency unit with coronavirus disease 2019 infection. Method: The retrospective study was conducted at a tertiary care hospital in Karachi, and comprised data of adult coronavirus disease 2019 patients of either gender admitted to the high dependency unit from March 1 to June 30, 2020. Outcomes were categorised as patients ‘recovered without deterioration’, ‘deteriorated but survived’, and ‘deteriorated but expired’. Data was analysed using SPSS 22. Results: Of the 525 patients with confirmed infection, 245(46.6%) were admitted to the high dependency unit. Leaving out 38(15.5%) cases with missing data, 207(84.5%) cases formed the study sample; 156(75.4%) males and 51(24.6%) females. The overall mean age was 56.9±14years (range: 24-86 years). The most common comorbid condition was hypertension 105(50.7%), and the most common reason for critical care was hypoxic respiratory failure 199(96.1%). Of the total, 153(74%) patients recovered, 31(15%) deteriorated, and mortality was the outcome in 23(11%). There was no significant effect of drug treatment on mortality (p>0.05). Age, multimorbidity and high D-Dimer level were significantly associated with disease progression and mortality (p<0.05). Conclusion: Mortality was high among coronavirus disease 2019 patients who were older and had multimorbidity. Key Words: COVID-19, In-hospital mortality, Multimorbidity, SARS-CoV-2 infection, Critical care outcomes. Author Biography Samar Fatima, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan Section of Internal Medicine,Department of Medicine Downloads Full Text Article Published 2023-07-15 How to Cite Fatima, S., Shamim, S., & Ejaz, T. (2023). Clinical outcomes and predictors of mortality in COVID-19 patients admitted to a High Dependency Unit in Pakistan-a cross-sectional study. Journal of the Pakistan Medical Association, 73(8), 1628–1633. https://doi.org/10.47391/JPMA.7288 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 8 (2023): AUGUST Section RESEARCH ARTICLE License Copyright (c) 2023 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.