Predictors of clinical outcomes in patients with sepsis: a retrospective study from a tertiary care hospital in Pakistan

Authors

  • Meher Angez 4th Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan https://orcid.org/0000-0002-4490-4453
  • Sahar Jessani Aga Khan University Hospital, Karachi, Pakistan
  • Manzar Abbas 5th Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan
  • Inaara Akbar 5th Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan
  • Russell Seth Martins Aga Khan University Hospital, Karachi, Pakistan
  • Ainan Arshad Department of Medicine, Aga Khan University, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.6818

Keywords:

Sepsis, Septic shock, Mortality, Morbidity

Abstract

Objective: To assess associations between various clinic-demographic factors and clinical outcomes among patients treated for sepsis.

Methods: The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of all patients aged >18 years diagnosed with sepsis from January to December 2019. Multivariable logistic regression was used to evaluate independent associations between predictors and outcomes. Data was analysed using R packages.

Results: Of the 1,136 patients, 621(54.6%) were male and 515(45.3%) were female. The overall mean age was 59.05±16.91 years. Female gender (odds ratio: 1.029; 95% confidence interval: 1.03-1.64) to be an independent predictor of septic shock, while hypertension (odds ratio0.75; 95% confidence interval: 0.59-0.95) emerged as a protective factor. Chronic kidney disease (odds ratio: 1.539; 95% confidence interval: 1.14-2.07) was an independent predictor of prolonged length of stay, while older age appeared to be protective (odds ratio: 0.98; 95% confidence interval: 0.98-0.99). Mortality was associated with a significantly lower odds of Escherichia coli on culture (odds ratio: 0.26; 95% confidence interval: 0.12-0.54).

Conclusion: Independent associations were found between specific patient characteristics and adverse clinical outcomes.

Key Words: Sepsis, Septic shock, Mortality, Morbidity.

Published

2024-02-11

How to Cite

Angez , M., Jessani, S., Abbas, M., Akbar, I., Russell Seth Martins, & Ainan Arshad. (2024). Predictors of clinical outcomes in patients with sepsis: a retrospective study from a tertiary care hospital in Pakistan. Journal of the Pakistan Medical Association, 74(3), 608–612. https://doi.org/10.47391/JPMA.6818

Issue

Section

STUDENT'S CORNER RESEARCH ARTICLE

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