Predictors of clinical outcomes in patients with sepsis: a retrospective study from a tertiary care hospital in Pakistan Authors Meher Angez 4th Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan https://orcid.org/0000-0002-4490-4453 Sahar Jessani Aga Khan University Hospital, Karachi, Pakistan Manzar Abbas 5th Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan Inaara Akbar 5th Year MBBS Student, Aga Khan University Hospital, Karachi, Pakistan Russell Seth Martins Aga Khan University Hospital, Karachi, Pakistan Ainan Arshad Department of Medicine, Aga Khan University, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.6818 Keywords: Sepsis, Septic shock, Mortality, Morbidity Abstract Objective: To assess associations between various clinic-demographic factors and clinical outcomes among patients treated for sepsis. Methods: The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data of all patients aged >18 years diagnosed with sepsis from January to December 2019. Multivariable logistic regression was used to evaluate independent associations between predictors and outcomes. Data was analysed using R packages. Results: Of the 1,136 patients, 621(54.6%) were male and 515(45.3%) were female. The overall mean age was 59.05±16.91 years. Female gender (odds ratio: 1.029; 95% confidence interval: 1.03-1.64) to be an independent predictor of septic shock, while hypertension (odds ratio0.75; 95% confidence interval: 0.59-0.95) emerged as a protective factor. Chronic kidney disease (odds ratio: 1.539; 95% confidence interval: 1.14-2.07) was an independent predictor of prolonged length of stay, while older age appeared to be protective (odds ratio: 0.98; 95% confidence interval: 0.98-0.99). Mortality was associated with a significantly lower odds of Escherichia coli on culture (odds ratio: 0.26; 95% confidence interval: 0.12-0.54). Conclusion: Independent associations were found between specific patient characteristics and adverse clinical outcomes. Key Words: Sepsis, Septic shock, Mortality, Morbidity. Downloads Full Text Article Published 2024-02-11 How to Cite Angez , M., Jessani, S., Abbas, M., Akbar, I., Russell Seth Martins, & Ainan Arshad. (2024). Predictors of clinical outcomes in patients with sepsis: a retrospective study from a tertiary care hospital in Pakistan. Journal of the Pakistan Medical Association, 74(3), 608–612. https://doi.org/10.47391/JPMA.6818 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 3 (2024): MARCH Section STUDENT'S CORNER RESEARCH ARTICLE License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.