Outcome of first relapse of Hodgkin lymphoma: Single Institution experience Authors Najma Shaheen Department of Pediatric Oncology, Shakut Khanum Cancer Hospital and Research Center, Lahore, Pakistan Ata Ur Rehman Maaz Department of Pediatric Hematology, Sidra Medical and Research Center, Doha, Qatar Muhammad Saghir Khan Department of Pediatric Hematology Division, Tawam Hospital, Alain, Abu Dhabi, UAE DOI: https://doi.org/10.47391/JPMA.1114 Abstract Objectives: 1:To determine outcome of first relapse of Hodgkin Lymphoma with standard dose chemotherapy. 2: To identify the prognostic factors predicting survival outcome in pediatric relapsed Hodgkin lymphoma. Methods: This was a retrospective analysis of 43 patients with HL who relapsed at least 3 months after completion of initial treatment from January 2001 to December 2010. Probabilities of OS, EFS and cumulative incidence were calculated by Kaplan-Meier method. Log rank tests were used to compare survival curves and p-value<0.05 was considered significant Results: Median age at relapse was 11± 3.3 years. In 72% of patients EPIC chemotherapy was employed. Median follow up of this cohort was 62 months (range 4-187 months). OS and EFS at 10 years was 54% and 35% respectively. On univariate analysis; initial disease stage (p=0.021), stage at relapse (p=0.003), treatment protocol (p=0.005), treatment responsiveness at initial two cycles of salvage chemotherapy (p=0.002) and at the end of treatment assessment (p=0.0009) were statistically significant factors. Multivariate cox regression analysis revealed disease stage at relapse (p=0.004), chemotherapy regimen (p=0.025) and end of treatment disease evaluation (p=0.005) as the statistically significant variables. Conclusion: First relapse of HL is potentially salvageable with standard dose chemotherapy with/without radiation. The patients with early stage at relapse and those with chemo-responsiveness can be effectively treated without ASCT. We observed improved outcome with EPIC chemotherapy regimen for the patients who had DFI of more 2 years. Downloads Full Text Article Published 2020-11-20 How to Cite Najma Shaheen, Ata Ur Rehman Maaz, & Muhammad Saghir Khan. (2020). Outcome of first relapse of Hodgkin lymphoma: Single Institution experience. Journal of the Pakistan Medical Association, 71(3), 1–15. https://doi.org/10.47391/JPMA.1114 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 71 No. 3 (2021): MARCH Section RESEARCH ARTICLE