Does drinking water with raised fluoride content affect the thyroid hormone status: A study from Thar Parker Pakistan Authors Iftekhar Ahmed Dow University of Health Sciences, Karachi, Pakistan Faiza Ghuman Dow University of Health Sciences, Karachi, Pakistan Salma Salman Dow University of Health Sciences, Karachi, Pakistan Ibraj Fatima 4th Year MBBS Student, Dow International Medical College, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.481 Abstract Objective: To determine the effect of consuming water with high fluoride content on thyroid hormone status. Method: The comparative cross-sectional study was conducted at Sammu Rind village of district Tharparkar, Pakistan, where ground water was the only source of drinking and had fluoride content >6-8mg/dL, and another set of people from Gadap Town, Karachi, where ground water had fluoride level of 0.3mg/L. Thyroid profile, including serum thyroid stimulating hormone, free triiodothyronine and free thyroxine, were checked for both the exposed and the unexposed groups, and data was cross-tabulated with thyroid profile to check statistical significance. Data was analysed using SPSS 20. Result: Of the 242 subjects, 121(50%) each were in the exposed and the unexposed group. Among the exposed, 15(12.4%) people had hypothyroidism, 104(86%) had euthyroid and 2(1.6%) had hyperthyroid. Corresponding values in the unexposed group were 10(8%), 105(87%) and 6(5%). The difference was not statistically significant (p>0.05). Key Words: Desert, Thyroid hormones, Fluorosis, Iodine, Hypothyroid, Hyperthyroidism. Downloads Full Text Article Published 2022-04-01 How to Cite Iftekhar Ahmed, Faiza Ghuman, Salma Salman, & Ibraj Fatima. (2022). Does drinking water with raised fluoride content affect the thyroid hormone status: A study from Thar Parker Pakistan. Journal of the Pakistan Medical Association, 72(2), 228–230. https://doi.org/10.47391/JPMA.481 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 2 (2022): FEBRUARY Section RESEARCH ARTICLE