Sexual behaviour change in seronegative limbic encephalitis due to the involvement of the left amygdala Authors Asuman Orhan Varoglu Department of Neurology, Medical School, Istanbul Medeniyet University, Istanbul, Turkey Hasan Turan Karatepe Department of Psychiatry, Medical School, Istanbul Medeniyet University, Istanbul, Turkey DOI: https://doi.org/10.47391/JPMA.4480 Abstract Limbic encephalitis (LE), a rare cause of encephalitis, generally presents with neuropsychiatric manifestations, memory deficits, seizures, and movement disorders. The case of a 41-year-old female patient with LE involving the left amygdala is presented. The patient was admitted to the emergency department with complaints of unconsciousness and seizures. Paraneoplastic and limbic markers were negative. This case was diagnosed as seronegative LE. Three to four months after the diagnosis, it was observed that her sexual preference changed to the female sex. No report has been published so far, concerning any case of LE associated with changes in sexual behaviour. The patient was treated with intravenous methylprednisolone (IVP) and triple antiepileptic therapy. After treatment, changes in sexual behaviour returned to the previous state. Keywords: limbic encephalitis, sexual behaviour, autoimmune encephalitis, paraneoplastic syndrome, left amygdala, homosexual. Downloads Full Text Article Published 2022-04-09 How to Cite Varoglu, A. O., & Karatepe, H. T. (2022). Sexual behaviour change in seronegative limbic encephalitis due to the involvement of the left amygdala. Journal of the Pakistan Medical Association, 72(8), 1656–1658. https://doi.org/10.47391/JPMA.4480 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 8 (2022): AUGUST Section CASE REPORT