Drug-induced duodenal perforation in the paediatric patient with thalassemia major, an unreported side effect of iron- chelating agent- a case report Authors Fatima Tuz Zahra Shakir Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan Rizwan Sultan Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan Riaz Siddiqui Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan Mohammad Zubair Shah Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan Ayesha Javed Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan Natasha Maryam Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan DOI: https://doi.org/10.47391/JPMA.4345 Abstract Duodenal ulcer disease is uncommon in paediatric age group. Its perforation is even rarer. However, it should be kept in mind when examining children with acute abdomen especially if there are signs of shock or possibility of upper gastrointestinal bleed. We report a case of a 6 years old female child, a known case of thalassemia major and taking oral Deferasirox since two years of age. She had atypical presentation as there was no previous history of peptic ulcer disease and she only suffered epigastric pain and vomiting for a week but due to lack of proper diagnosis at a local clinic developed duodenal ulcer perforation, which was ultimately diagnosed at a tertiary care hospital and managed with Graham Patch Closure. Keywords: Paediatric age group, duodenal ulcer, duodenal perforation, epigastric pain, Desferasirox. Author Biographies Rizwan Sultan, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan GENERAL SURGEON Riaz Siddiqui, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan HEAD OF DEPARTMENT AND GENERAL SURGEON Mohammad Zubair Shah, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan GENERAL SURGEON Ayesha Javed, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan GENERAL SURGEON Natasha Maryam, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan SURGERY RESIDENT Additional Files PDF Published 2022-02-23 How to Cite Shakir, F. T. Z., Sultan, R., Siddiqui, R., Shah, M. Z., Javed, A., & Maryam, N. (2022). Drug-induced duodenal perforation in the paediatric patient with thalassemia major, an unreported side effect of iron- chelating agent- a case report. Journal of the Pakistan Medical Association. https://doi.org/10.47391/JPMA.4345 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue A Head of Print Section Case Report