Drug-induced duodenal perforation in the paediatric patient with thalassemia major, an unreported side effect of iron- chelating agent- a case report

Authors

  • Fatima Tuz Zahra Shakir Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan
  • Rizwan Sultan Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan
  • Riaz Siddiqui Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan
  • Mohammad Zubair Shah Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan
  • Ayesha Javed Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan
  • Natasha Maryam Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan

DOI:

https://doi.org/10.47391/JPMA.4345

Abstract

Duodenal ulcer disease is uncommon in paediatric age group. Its perforation is even rarer. However, it should be kept in mind when examining children with acute abdomen especially if there are signs of shock or possibility of upper gastrointestinal bleed. We report a case of a 6 years old female child, a known case of thalassemia major and taking oral Deferasirox since two years of age. She had atypical presentation as there was no previous history of peptic ulcer disease and she only suffered epigastric pain and vomiting for a week but due to lack of proper diagnosis at a local clinic developed duodenal ulcer perforation, which was ultimately diagnosed at a tertiary care hospital and managed with Graham Patch Closure.

Keywords: Paediatric age group, duodenal ulcer, duodenal perforation, epigastric pain, Desferasirox.

Author Biographies

Rizwan Sultan, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan

GENERAL SURGEON

Riaz Siddiqui, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan

HEAD OF DEPARTMENT AND GENERAL SURGEON

Mohammad Zubair Shah, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan

GENERAL SURGEON

Ayesha Javed, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan

GENERAL SURGEON

Natasha Maryam, Department of General Surgery, Islamabad Medical Complex, Islamabad, Pakistan

SURGERY RESIDENT

Additional Files

Published

2022-02-23

How to Cite

Shakir, F. T. Z., Sultan, R., Siddiqui, R., Shah, M. Z., Javed, A., & Maryam, N. (2022). Drug-induced duodenal perforation in the paediatric patient with thalassemia major, an unreported side effect of iron- chelating agent- a case report. Journal of the Pakistan Medical Association. https://doi.org/10.47391/JPMA.4345

Issue

Section

Case Report