Correlation of insulin resistance with neutrophil to lymphocyte ratio and serum ferritin in male patients of metabolic syndrome Authors Uzma Zafar Department of Physiology, Lahore Medical and Dental College, University of Health Sciences, Lahore, Pakistan Zaima Ali Department of Physiology, Lahore Medical and Dental College, University of Health Sciences, Lahore, Pakistan Saba Khaliq Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan Khalid Pervaiz Lone Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.3300 Abstract Objective: To determine the correlation of insulin resistance with neutrophil-to-lymphocyte ratio and serum ferritin, and to evaluate whether NLR and serum ferritin can predict insulin resistance in metabolic syndrome. Method: The cross-sectional analytical study was conducted at the University of Health Sciences, Lahore, Pakistan, from July 2016 to 2019, and comprised male patients of metabolic syndrome and healthy controls. The correlation involving insulin resistance, serum ferritin and neutrophil-to-lymphocyte ratio was determined. Data was analysed using SPSS 22. Results: Of the 210 subjects, 160(76.2%) were cases with a median age of 45 years (interquartile range: 39-50 years), and 50(23.8%) were controls with a median age of 41 years (interquartile range: 35-50 years). Serum ferritin, alanine aminotransferase, total neutrophil count, lymphocyte count and neutrophil-to-lymphocyte ratio were significantly higher among the cases than the controls (p<0.05). Significant positive correlation of insulin resistance was observed with serum ferritin and neutrophil-to-lymphocyte ratio (p<0.05)) among the cases. Neutrophil-to-lymphocyte ratio significantly predicted insulin resistance among the cases (p<0.05). Conclusion: Neutrophil-to-lymphocyte ratio was fund to be a significant predictor of insulin resistance in metabolic syndrome. Key Words: Neutrophil to lymphocyte ratio, Ferritin, Type 2 diabetes. Insulin resistance. Continue... Downloads Full Text Article Published 2022-04-05 How to Cite Uzma Zafar, Ali, Z., Khaliq, S., & Lone, K. P. (2022). Correlation of insulin resistance with neutrophil to lymphocyte ratio and serum ferritin in male patients of metabolic syndrome . Journal of the Pakistan Medical Association, 72(4), 696–701. https://doi.org/10.47391/JPMA.3300 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 4 (2022): APRIL Section Research Article