Obesity And The Spleen Authors Sanjay Kalra Department of Endocrinology, Bharti Hospital, Karnal, India; University Centre for Research & Development, Chandigarh University, Mohali, India Suneet Kumar Vermaz Department of Medicine, Alchemist Hospital, Panchkula India; Sparsh Clinic, Panchkula, India Nitin Kapoor Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India; Non communicable disease unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia DOI: https://doi.org/10.47391/JPMA.25-63 Abstract This review describes the relationship of splenomegaly, or“splenic obesity”, with metabolic syndrome, obesity andmetabolic – associated steatohepatic disease (MAFLD),based on animal and human studies. The spleen isenlarged in obesity. It may play a protective role againstobesity-associated inflammation and complications. Thisprotection may be lost after splenomegaly. Persons withsplenic disease must be evaluated for obesity, and viceversa and counselled to avoid injury to the organ.Keywords: MASLD, NAFLD, obesity, overweight, portalhypertension, spleen, splenectomy, weight Downloads Full Text Article Published 2025-07-28 How to Cite Sanjay Kalra, Suneet Kumar Vermaz, & Nitin Kapoor. (2025). Obesity And The Spleen. Journal of the Pakistan Medical Association, 75(8), 1298–1300. https://doi.org/10.47391/JPMA.25-63 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 8 (2025): AUGUST Section BAROCRINOLOGY License Copyright (c) 2025 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.