Role of Machine Learning in Liquid Biopsy of Brain Tumours Authors Zanib Javed Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan. Saqib Kamran Bakhshi Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan. Saad Akhtar Khan Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan. Muhammad Shahzad Shamim Section of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan. DOI: https://doi.org/10.47391/JPMA.24-46 Abstract Liquid biopsy has multiple benefits and is used extensivelyin other fields of oncology, but its role in neuro-oncologyhas been limited so far. Multiple tumour-derived materialslike circulating tumour cells (CTCs), tumour-educatedplatelets (TEPs), cell-free DNA (cfDNA), circulating tumourDNA (ctDNA), and miRNA are studied in CSF, blood (plasma,serum) or urine. Large and complex amounts of data fromliquid biopsy can be simplified by machine learning usingvarious algorithms. By using this technique, we candiagnose brain tumours and differentiate low versus highgradeglioma and true progression frompseudo-progression. The potential of liquid biopsy in braintumours has not been extensively studied, but it has abright future in the coming years. Here, we present aliterature review on the role of machine learning in liquidbiopsy of brain tumours. Downloads Full Text Article Published 2024-05-24 How to Cite Zanib Javed, Saqib Kamran Bakhshi, Saad Akhtar Khan, & Muhammad Shahzad Shamim. (2024). Role of Machine Learning in Liquid Biopsy of Brain Tumours. Journal of the Pakistan Medical Association, 74(6), 1194–1196. https://doi.org/10.47391/JPMA.24-46 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 6 (2024): JUNE Section EVIDENCE BASED NEURO-ONCOLOGY License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.