Semaglutide: an emerging treatment option for patients with obesity related HFpEF Authors Sanya Ashraf Khaskheli 4th Year MBBS Student, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan Najaf Ahmed Rajpar 3rd Year MBBS Student, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan DOI: https://doi.org/10.47391/JPMA.20158 Keywords: semaglutide, heart failure, obesity, ncd Abstract Dear Madam, Heart failure is a key contributor to patient morbidity and mortality and affects a staggering 64 million individuals around the globe1. An important sub-phenotype of heart failure is HFpEF, which is characterised by a left ventricular ejection fraction (LVEF) of 50 per-cent. Alarmingly, the incidence of this subtype has been rising globally, making the need for new treatment options extremely crucial2. Initially, the use of Semaglutide, a glucagon-like peptide-1 receptor agonist, showed favourable outcomes in cardiac function of mice. This study observed that weight loss achieved using Semaglutide was met with improvements in several factors associated with HFpEF (reduced LV hypertrophy and fibrosis, improved diastolic function, reduced lung congestion and improved exercise capacity) as compared to weight loss achieved through simple dietary means3. A step further in this direction is a clinical trial that shows that a weekly dosage of 2.4mg of Semaglutide in obesity related HFpEF patients is associated with significantly reduced symptoms and physical limitations, improved exercise function and greater weight loss than placebo4. Of the several parameters observed, improvements in CSS (Clinical Survey Score) of KCCQ (Kansas City Cardiomyopathy Questionnaire) and six minute walking distance were the most clinically meaningful. These promising findings are of particular value to Pakistani population, which has been prey to obesity and HF owing to Westernised eating habits, sedentary lifestyles and fewer healthcare facilities. In addition, South Asians have more fat content per BMI as compared to their white counterparts which coupled with the rising trends in NCD risks in South Asia5, are an immediate call for innovation in therapeutics. Semaglutide, considering its array of cardiometabolic benefits, may provide our doctors with a chance to step away from prescribing long lists of medications that are conventionally given to HF patients for symptom improvement. In a low- income country like Pakistan, this will ensure a better drug compliance and reduced disease burden. It is high time that we tap into the potential of Semaglutide and test its efficacy of it in our native population and take strides in ensuring its easy availability. Author Biographies Sanya Ashraf Khaskheli, 4th Year MBBS Student, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan 4th Year MBBS Student, Liaquat University of Medical and Health Sciences, Jamshoro Najaf Ahmed Rajpar, 3rd Year MBBS Student, Bilawal Medical College, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan 3rd Year MBBS Student, Bilawal Medical College, Jamshoro Downloads Full Text Article Published 2024-08-23 How to Cite Khaskheli, S. A., & Rajpar, N. A. (2024). Semaglutide: an emerging treatment option for patients with obesity related HFpEF. Journal of the Pakistan Medical Association, 74(9), 1743–1743. https://doi.org/10.47391/JPMA.20158 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 9 (2024): SEPTEMBER Section STUDENT'S CORNER LETTER TO THE EDITOR License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.