Association of vitamin D levels with preeclampsia Authors Sana Shahid Sir Syed Medical College, Karachi, Pakistan Asma Ladak 3rd Year Medical Student, Medical College, Aga Khan University, Karachi, Pakistan Syeda Sadia Fatima Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan Fatima Abid Zaidi 4 Jinnah Sindh Medical University, Karachi, Pakistan Sabah Farhat Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.414 Abstract Abstract Objectives: This study was aimed to assess maternal vitamin D status during pregnancy and determine the association between maternal 25(OH) D levels with risk of preeclampsia (PE). Methods: A cross-sectional study was conducted with 172 pregnant women recruited from JPMC between January and December 2017 who were divided as normotensive (n=80) and pre-eclamptic (n=92) groups. Blood pressure was recorded at 20 and 32 weeks of gestation. Five ml of blood sample was collected at 20 weeks of gestation to assess the vitamin D levels by commercially available ELISA assay. Results: PE group had a significantly higher systolic (p<0.001) and diastolic (p<0.001) blood pressure at 20 weeks of gestation. Vitamin D levels were reported to be significantly lower (p<0.001) in the PE group (17.97±9.38 ng/ml) as compared to normotensive group (42.18±25.17 ng/ml). A strong negative correlation of Vitamin D levels with systolic blood pressure (r=-0.428; p<0.001) and diastolic blood pressure (r= -0.375; p<0.001) was found. Conclusion: This study found a strong relationship between low vitamin D levels and pre-eclamptic manifestation. Keywords: Vitamin D; Pre-eclampsia; Pregnancy; Hypertension. Continuous.... Additional Files PDF Published 2020-10-15 How to Cite Sana Shahid, Asma Ladak, Syeda Sadia Fatima, Fatima Abid Zaidi, & Sabah Farhat. (2020). Association of vitamin D levels with preeclampsia. Journal of the Pakistan Medical Association. https://doi.org/10.47391/JPMA.414 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue A Head of Print Section Research Article