Immunohistochemical expression of MUC4 in different grades of Head and Neck Squamous cell carcinoma Authors Naila Umer Department of Oral Pathology, University of Health Sciences, Lahore, Pakistan Nadia Naseem Department of Histopathology, University of Health Sciences, Lahore, Pakistan Saima Chaudhry Department of Oral Pathology, University of Health Sciences, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.217 Abstract Abstract Objective: To determine immunohistochemical expression of Mucin 4 in head and neck squamous cell carcinoma and its different histological grades among patients reporting to various tertiary care hospitals in an urban setting. Method: The descriptive study was conducted at the Department of Oral Pathology / Morbid Anatomy and Histopathology, University of Health Sciences, Lahore, Pakistan, from January to July 2017, and comprised cases of head and neck squamous cell carcinoma. Histological diagnosis and grading was done for each case. Haematoxylin and eosin stain followed by immunohistochemistry was done. Relation of Mucin 4 expression with tumour types was explored. SPSS 20 was used for statistical analysis. Result: Of the 63 samples, 40(63.5%) were from male patients. The overall mean age of the patients was 53±3.77 years. Mucin 4 expression was positive in 47(74.6%) cases. Of them, 16(34%) had grade 1 tumour, 28(59.6%) had grade 2 and 3(6.4%) had grade 3 tumour. tumourThere was a significant relation (p=0.03) between tumour grades and intensity of Mucin 4 expression. tumour Conclusion: Upregulation of Mucin 4in tumour tissue with no expression in normal epithelium was found, and loss of Mucin 4 expression with increase in tumour grade was noted. Key Words: Mucin 4, MUC4, Squamous cell carcinoma of head and neck, HNSCC, Immunohistochemistry Continuous... Additional Files PDF Published 2020-10-13 How to Cite Naila Umer, Nadia Naseem, & Saima Chaudhry. (2020). Immunohistochemical expression of MUC4 in different grades of Head and Neck Squamous cell carcinoma. Journal of the Pakistan Medical Association, 1–14. https://doi.org/10.47391/JPMA.217 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue A Head of Print Section Research Article