The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B Authors Habip Gedik Department of Infectious Disease and Clinical Microbiology, University of Health Sciences and Ministry of Health, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey Muge Sonmezisik Department of Infectious Disease and Clinical Microbiology, University of Health Sciences and Ministry of Health, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey DOI: https://doi.org/10.47391/JPMA.1135 Abstract Abstract We report two treatment-naïve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the Department of Infectious Diseases and Clinical Microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TDF) monotherapy presumably due to an antiviral-drug resistance was noted. A sustained viral response with TDF (245 mg) or Tenofovir Alafenamide (TAF, 25 mg) + Entecavir (ETV, 1 mg) combination therapy was observed after failure with TDF monotherapy. A combination therapy with TDF (245 mg) or TAF (25 mg) +ETV (1 mg) is efficacious in naïve patients with a partial response to TDF monotherapy. Keywords: Chronic hepatitis B, Tenofovir, partial response, Entecavir, combination therapy Additional Files PDF Published 2020-10-05 How to Cite Gedik, H. ., & Muge Sonmezisik. (2020). The partial virological response to Tenofovir monotherapy in naïve patients with chronic hepatitis B. Journal of the Pakistan Medical Association, 1–12. https://doi.org/10.47391/JPMA.1135 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue A Head of Print Section Case Report