Severe mixed mitral valve disease due to massive mitral annular calcification — a case report and literature review Authors Fateh Ali Tipoo Sultan Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan. Sheema Saadia Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan. DOI: https://doi.org/10.47391/JPMA.11-1172 Abstract We present an unusual case of massive mitral annular calcification (MAC) leading to severe mixed mitral valve disease viz: severe mitral regurgitation and severe mitral stenosis. To our knowledge severe mixed mitral valve disease secondary to MAC is extremely rare. The patient presented with worsening shortness of breath and signs of congestive heart failure. Echocardiographic examination revealed massive mitral annular calcification. Despite the massive annular calcification, she had experienced neither embolism nor endocarditis in the past. Because of severe symptomatic mitral regurgitation and mitral stenosis, surgery was advised, however the patient declined. Continuous... Downloads Full Text Article Published 2022-05-07 How to Cite Fateh Ali Tipoo Sultan, & Sheema Saadia. (2022). Severe mixed mitral valve disease due to massive mitral annular calcification — a case report and literature review. Journal of the Pakistan Medical Association, 72(01), 155. https://doi.org/10.47391/JPMA.11-1172 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 72 No. 01 (2022): JANUARY Section CASE REPORT