Gut microbiota and myeloproliferative neoplasms

Authors

  • Adeniyi Abraham Adesola College of Medicine, University of Ibadan, Nigeria. College Research and Innovation Hub, Ibadan, Nigeria
  • Yongfeng Chen Department of Basic Medical Sciences, School of Medicine of Taizhou University, Taizhou University, Taizhou 318000, Zhejiang Province, China.
  • Mihnea Alexandru Gaman Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474, Bucharest, Romania, Department of Hematology, Centre of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania, Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, Romanian Academy, Bucharest 030304, Romania

DOI:

https://doi.org/10.47391/JPMA.23-99

Abstract

The human gut microbiota refers to the collective assembly of microorganisms inhabiting and colonizing the gastrointestinal tract, including bacteria, archaea, and eukarya.1 This intricate microbial ecosystem exists in a symbiotic relationship with the host, with trillions of microorganisms playing key roles in maintaining human health.2 Firmicutes and Bacteroidetes represent the predominant bacterial phyla that form the intestinal microbiome.2 The gut microbiota has developed adaptive mechanisms to promote its survival within the gastrointestinal tract. Development of the intestinal microbiome has been depicted and seems to be influenced by a variety of factors, e.g., mode of delivery, diet during infancy and adulthood, illnesses, and antibiotic treatment causing variation in the composition of the microbiota.3 Before the age of three, children’s intestinal microbiome already resembles the gut microbiota of adult individuals in terms of functional capabilities, diversity, and composition.4 The gut microbiota offers numerous benefits to the host as its metabolic activity is responsible for the generation of short-chain fatty acids which are a source of energy for the host, and for the fermentation of carbohydrates leading to the synthesis of oxalates, reducing the risk of oxalate stones in the kidney.5 In addition, the microbiota promotes lipid metabolism, vitamin synthesis, polyphenol breakdown, drug metabolism, immunomodulation, which offers immune-protection, and maintains the structural integrity of the gastrointestinal tract.3 Therefore, the gut microbiota represents an intricate microbial ecosystem that plays a critical role in maintaining human health.

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Published

2023-11-28

How to Cite

Adeniyi Abraham Adesola, Yongfeng Chen, & Mihnea Alexandru Gaman. (2023). Gut microbiota and myeloproliferative neoplasms. Journal of the Pakistan Medical Association, 73(12), 2334–2335. https://doi.org/10.47391/JPMA.23-99

Issue

Section

EDITORIAL

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