Insulinoma; a diagnostic challenge: a case report Authors Wania Rafaey Department of Endocrinology, Shaukat Khanum Cancer Memorial Hospital and Research Centre, Lahore, Pakistan Asim Munir Alvi Department of Endocrinology, Shaukat Khanum Cancer Memorial Hospital and Research Centre, Lahore, Pakistan Sidra Aslam Department of Endocrinology, Shaukat Khanum Cancer Memorial Hospital and Research Centre, Lahore, Pakistan Ahmed Imran Siddiqui Department of Endocrinology, Shaukat Khanum Cancer Memorial Hospital and Research Centre, Lahore, Pakistan Waqas Shafiq Department of Endocrinology, Shaukat Khanum Cancer Memorial Hospital and Research Centre, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.11001 Keywords: insulinoma, insulin levels, endoscopic ultrasound Abstract Insulinoma is a pancreatic neuroendocrine tumour that primarily leads to episodes of hypoglycaemia due to inappropriate and excessive secretion of insulin. It classically presents with neuroglycopenic and autonomic sympathetic symptoms, which resolve promptly with glucose administration. Elevated level of insulin and C-peptide in the presence of low plasma glucose level and absence of plasma sulfonylurea are diagnostic features. Localisation of the tumour is essential before surgery. However, Insulinoma is difficult to diagnose due to its ambiguous location and insidious course. This is the case of a young male who had 6 months history of adrenergic and neuroglycopenic symptoms, including one episode of seizure. His symptoms resolved with the consumption of high glycaemic indexed food. Biochemical tests were suggestive of insulinoma, but non-invasive imaging techniques including computer tomography (CT) and magnetic resonance imaging (MRI) could not localise the tumour. In this case, pancreatic insulinoma was localised by endoscopic pancreatic ultrasound (EUS). He underwent successful resection of the tumour and his symptoms resolved completely post-surgery. Keywords: Insulinoma, insulin levels, endoscopic ultrasound. Downloads Full Text Article Published 2024-12-23 How to Cite Rafaey, W., Alvi, A. M., Aslam, S., Siddiqui, A. I., & Shafiq, W. (2024). Insulinoma; a diagnostic challenge: a case report. Journal of the Pakistan Medical Association, 75(1), 122–124. https://doi.org/10.47391/JPMA.11001 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 1 (2025): JANUARY Section CASE REPORT License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.