A short communication regarding the trends and prevalence of H. Pylori in unselected gastric mucosal biopsy samples at a tertiary care hospital in Karachi, Pakistan: a five-year retrospective Authors Naseem Ahmed Department of Pathology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan Sambreen Zameer Department of Pathology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan Shamas Ghazanfar 4th Year MBBS Student, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan https://orcid.org/0000-0002-3659-4491 Zarmina Islam 4th Year MBBS Student, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan Hafsa Nazir Jatoi 4th Year MBBS Student, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan Manal Khan 4th Year MBBS Student, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.10957 Keywords: Gastritis, Antrum, H. Pylori, Gastric ulcer Abstract A spiral gram-negative bacteria, known as helicobacter pylori, is frequently discovered in the stomach and is linked to a number of clinical disorders. Understanding its prevalence and trends is crucial for both improved clinical outcomes as well as greater epidemiological insight into the region. The current retrospective study was planned to analyse the prevalence and frequency trends of helicobacter pylori in gastric mucosal samples from a Karachi-based tertiary care centre. Data from a 5-year period was analysed. Sampled individuals' age, gender, site of infection and histopathological findings were noted. A decreasing trend in helicobacter pylori infections in biopsy samples was observed. Gender and age showed no significant association (p>0.05), while infection site and histopathological findings exhibited significant correlations (p<0.05). Antrum predominated for all types of gastritis. The study highlighted a declining trend in helicobacter pylori prevalence in Karachi over 5 years. Further multicentre studies with larger samples may provide deeper insights into helicobacter pylori trends in Pakistan. Key Words: Gastritis, Antrum, H. Pylori, Gastric ulcer. Downloads Full Text Article Published 2024-12-23 How to Cite Ahmed, N., Zameer, S., Ghazanfar , S., Islam , Z., Jatoi, H. N., & Khan, M. (2024). A short communication regarding the trends and prevalence of H. Pylori in unselected gastric mucosal biopsy samples at a tertiary care hospital in Karachi, Pakistan: a five-year retrospective. Journal of the Pakistan Medical Association, 75(1), 100–102. https://doi.org/10.47391/JPMA.10957 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 75 No. 1 (2025): JANUARY Section SHORT COMMUNICATION License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.