Olfactory neuroblastoma: a rare sinonasal malignancy Authors Athar Adnan Uppal Department of ENT, Ghurki Trust and Teaching Hospital, Lahore, Pakistan Saira Zaman Department of ENT, Ghurki Trust and Teaching Hospital, Lahore, Pakistan Ayesha Shahbaz Department of ENT, Ghurki Trust and Teaching Hospital, Lahore, Pakistan Sadia Iram 4th Year MBBS Student, Lahore Medical and Dental College, Lahore, Pakistan DOI: https://doi.org/10.47391/JPMA.10735 Keywords: Olfactory neuroblastoma, Esthesioneuroblastoma, Pseudo-rosettes, Lateral rhinotomy, Nasal cavity, synaptophysin positive Abstract Olfactory neuroblastoma is a rare malignant tumour arising from the olfactory nerve and extending into the nasal cavity. In this case report, the case of a 42-year-old male is presented. The patient had a two-month history of progressive nasal blockage and episodes of epistaxis. No complaint of anosmia or facial pain was reported. All the necessary examinations were performed. Upon investigation, the CT scan and MRI showed a polypoid mass involving the right maxillary sinus, eroding the medial wall and expanding into the osteo-meatal complex. The diagnosis of olfactory neuroblastoma was confirmed through histopathological examination and further validated by immunohistochemistry as it was positive for synaptophysin, chromogranin, gamma enolase, and neurofilament. On staging, the tumour was Kadish B. The mass was excised by lateral rhinotomy. The patient was kept on radiotherapy and was free from recurrence upon follow-up 10 months later. ---Continue Downloads Full Text Article Published 2024-06-28 How to Cite Uppal, A. A., Zaman, S., Shahbaz, A., & Iram, S. (2024). Olfactory neuroblastoma: a rare sinonasal malignancy. Journal of the Pakistan Medical Association, 74(7), 1370–1373. https://doi.org/10.47391/JPMA.10735 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 7 (2024): JULY Section CASE REPORT License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.