Tackling a deadly global phenomenon: sepsis induced coagulopathy: a narrative review Authors Ainan Arshad Department of Internal Medicine, Aga Khan University, Karachi, Pakistan Warda Ahmed 3rd Year MBBS Student, Aga Khan University Medical College, Karachi, Pakistan Naureen Rehman Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan Zehra Naseem Aga Khan University Medical College, Karachi, Pakistan Zara Ghos Aga Khan University Medical College, Karachi, Pakistan DOI: https://doi.org/10.47391/JPMA.10194 Keywords: Sepsis induced coagulopathy, Anticoagulants, Coagulants, DIC Abstract Sepsis is a potentially fatal illness marked by organ failure and the two main causes of which are shock and disseminated intravascular coagulation. Multi-organ dysfunction in sepsis is mediated by the inflammatory cytokine storm, while sepsis induced coagulopathy is mediated and accelerated by activation of pro-coagulative mechanisms. Regardless of the severity of sepsis, disseminated intravascular coagulation is a potent predictor of mortality in septic patients. Additionally, oxidative stress in sepsis causes renal ischemia and eventually acute kidney injury. The first and foremost goal is to initiate resuscitation immediately, with treatment mainly focusing on maintaining a balance of coagulants and anticoagulants. A simpler and more universal diagnostic criteria is likely to improve studies on the spectrum associated with sepsis. Key Words: Sepsis induced coagulopathy, Anticoagulants, Coagulants, DIC. Downloads Full Text Article Published 2024-04-22 How to Cite Ainan Arshad, Ahmed, W., Rehman, N., Naseem, Z., & Ghos, Z. (2024). Tackling a deadly global phenomenon: sepsis induced coagulopathy: a narrative review. Journal of the Pakistan Medical Association, 74(5), 959–966. https://doi.org/10.47391/JPMA.10194 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 74 No. 5 (2024): MAY Section Narrative Review License Copyright (c) 2024 Journal of the Pakistan Medical Association This work is licensed under a Creative Commons Attribution 4.0 International License.