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December 2018, Volume 68, Issue 12


Infantile Hepatic Hemangioma

Zeshan Shabbir  ( Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan )
Ainy Javaid  ( Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan )
Islah Ud Din  ( Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan )


Infantile hepatic hemangioma (IHH) historically called “hemangiomaendothelioma” refers to visceral manifestation of infantile hemangioma. The diagnosis of infantile hepatic hemangioma is primarily based on the radiological features. We present a case of 4 month old infant who presented with abdominal distention. Contrast enhanced CT demonstrated typical features of diffuse infantile hepatic hemangiomas.
Infantile hepatic hemangioma, IHH, benign tumour, diffuse type.

A 4 month old infant presented with abdominal distention. His other symptoms included bleeding from the nose and mouth. Contrast enhanced CT scan was performed which revealed numerous vascularized hepatic lesions with peripheral enhancement in arterial phase (Fig. 1a) along with gradual filling in portal venous and delayed phase (Fig. 1b &c and Fig. 2, 3). In addition, change in caliber of the abdominal aorta was noted below the celiac axis level (Fig. 2); which is another characteristic finding in in IHH. This is due to preferentially increased blood flow to the liver via celiac axis. IHH is a subclass of infantile hemangiomas which constitute most common self-limiting benign tumours of infancy1. IHH is the most common hepatic vascular tumour in the first 6 months of life with a predilection for females (3:1)2. It has 3 patterns focal, multifocal or diffuse3. Despite the benign nature of IHHs, multiple and diffuse lesions can present with life-threatening complications including severe hypothyroidism and cardiac failure, requiring prompt medical intervention. Therefore, a proper diagnosis is of pivotal importance. In case of diffuse involvement, a confident diagnosis can be made based on radiological features alone as in the case presented here. The characteristic radiographic appearance of lesions on contrastenhanced CT includes well defined margins,hyper acute (i.e arterial) peripheral nodular/ corrugated enhancement with progressive centripetal filling in portal venous phase without any vascular invasion or lymphadenopathy and sometimes associated with abrupt narrowing of aortic caliber below celiac axis4.


1. Itinteang T, Withers AH, Davis PF, Tan ST. Biology of infantile hemangioma. Front Surg. 2014;1:38.
2. Gnarra M, Behr G, Kitajewski A, Wu JK, Anupindi SA, Shawber CJ,et al. History of the infantile hepatic hemangioma: From imaging to generating a differential diagnosis. World J Clin Pediatr. 2016;5:273-80.
3. Christison-Lagay ER, Burrows PE, Alomari A, Dubois J, Kozakewich HP, Lane TS et al. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg. 2007;42:62-7.
4. Chung EM, Cube R, Lewis RB, Conran RM. From the archives of the AFIP: Pediatric liver masses: radiologic-pathologic correlation part 1. Benign tumors. Radiographics. 2010 ;30:801-26. 

Journal of the Pakistan Medical Association has agreed to receive and publish manuscripts in accordance with the principles of the following committees: